PDB entry 4krp

View 4krp on RCSB PDB site
Description: Nanobody/VHH domain 9G8 in complex with the extracellular region of EGFR
Class: transferase/immune system
Keywords: cell surface receptor, glycoprotein, nanobody, VHH domain, Camelid VH domain, antibody, antigen, antibody complex, TRANSFERASE-IMMUNE SYSTEM complex
Deposited on 2013-05-16, released 2013-08-28
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-08-28, with a file datestamp of 2013-08-23.
Experiment type: XRAY
Resolution: 2.82 Å
R-factor: 0.217
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Nanobody/VHH domain 9G8
    Species: LAMA GLAMA [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 4KRP (0-End)
    Domains in SCOPe 2.07: d4krpb_
  • Chain 'C':
    Compound: Cetuximab light chain
    Species: Mus musculus, Homo sapiens [TaxId:10090, 9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4KRP (0-210)
    Domains in SCOPe 2.07: d4krpc1, d4krpc2
  • Chain 'D':
    Compound: Cetuximab heavy chain
    Species: Mus musculus, Homo sapiens [TaxId:10090, 9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4KRP (0-End)
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4krpB (B:)
    evqlvesggglvqaggslrlscaasgrtfssyamgwfrqapgkerefvvainwssgstyy
    adsvkgrftisrdnakntmylqmnslkpedtavyycaagyqinsgnynfkdyeydywgqg
    tqvtvssalehhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4krpB (B:)
    evqlvesgggllscaasgrtfssyamgwfrqapgkerefvvainwssgstyyadsvkgrf
    tisrdnakntmylqmnslkpedtavyycaagyqinsgnynfkdyeydywgqgtqvt
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4krpC (C:)
    dilltqspvilsvspgervsfscrasqsigtnihwyqqrtngsprllikyasesisgips
    rfsgsgsgtdftlsinsvesediadyycqqnnnwpttfgagtklelkrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnr
    

  • Chain 'D':
    No sequence available.