PDB entry 4kg8

View 4kg8 on RCSB PDB site
Description: Crystal structure of light mutant
Class: cytokine
Keywords: STRUCTURAL GENOMICS, PSI-BIOLOGY, NEW YORK STRUCTURAL GENOMICS RESEARCH CONSORTIUM, NYSGRC, IMMUNITY, TNF SUPERFAMILY, HVEM, DCR3, N-GLYCOSYLATION, MEMBRANE, SECRETED PROTEIN, CYTOKINE, ATOMS-TO-ANIMALS: THE IMMUNE FUNCTION NETWORK, JELLY-ROLL FOLD, BIND TNF RECEPTOR HVEM AND LTBR, LTBR, Protein Structure Initiative, IFN
Deposited on 2013-04-28, released 2013-08-07
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-09-18, with a file datestamp of 2013-09-13.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: 0.215
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Tumor necrosis factor ligand superfamily member 14
  Species: Homo sapiens [TaxId:9606]
  Gene: TNFSF14, HVEML, LIGHT, UNQ391/PRO726
  Database cross-references and differences (RAF-indexed):
  • Uniprot O43557 (Start-157)
    • engineered mutation (112-113)
    • engineered mutation (115)
    • engineered mutation (131)
  Domains in SCOPe 2.05: d4kg8a_
• Chain 'B':
  Compound: Tumor necrosis factor ligand superfamily member 14
  Species: Homo sapiens [TaxId:9606]
  Gene: TNFSF14, HVEML, LIGHT, UNQ391/PRO726
  Database cross-references and differences (RAF-indexed):
  • Uniprot O43557 (Start-157)
    • engineered mutation (113)
    • engineered mutation (115)
    • engineered mutation (131)
  Domains in SCOPe 2.05: d4kg8b_
• Chain 'C':
  Compound: Tumor necrosis factor ligand superfamily member 14
  Species: Homo sapiens [TaxId:9606]
  Gene: TNFSF14, HVEML, LIGHT, UNQ391/PRO726
  Database cross-references and differences (RAF-indexed):
  • Uniprot O43557 (Start-157)
    • engineered mutation (113)
    • engineered mutation (115)
    • engineered mutation (131)
• Heterogens: HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >4kg8A (A:)
  liqerrshevnpaahltganssltgsggpllwetqlglaflrglsyhdgalvvtkagyyy
  iyskvqlggvgcplglastithglykrtprypeelellvsqqspcgratssssnwfdssf
  lggvvhleageevvvrvlderlvrlrdgtrsyfgafmv
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >4kg8A (A:)
  vnpaahltganssltgsggpllwetqlglaflrglsyhdgalvvtkagyyyiyskvqlgg
  vgtithglykrtprypeelellvsqqspsnwfdssflggvvhleageevvvrvlderlgt
  rsyfgafmv
  

  
  
• Chain 'B':
  Sequence, based on SEQRES records: (download)
  

  >4kg8B (B:)
  liqerrshevnpaahltganssltgsggpllwetqlglaflrglsyhdgalvvtkagyyy
  iyskvqlggvgcplglastithglykrtprypeelellvsqqspcgratssssnwfdssf
  lggvvhleageevvvrvlderlvrlrdgtrsyfgafmv
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >4kg8B (B:)
  npaahltganssgsggpllwetqlglaflrglsyhdgalvvtkagyyyiyskvqlgasti
  thglykrtypeelellvsqqspnwfdssflggvvhleageevvvrvldegtrsyfgafmv
  

  
  
• Chain 'C':
  No sequence available.