PDB entry 4ke5

View 4ke5 on RCSB PDB site
Description: HCV NS5B GT1B N316Y with GSK5852
Class: replication/replication inhibitor
Keywords: HCV Polymerase, HCV NS5B, Site IV Inhibitor, boron, P66, P70, RNA directed RNA Polymerase, Polymerase, RNA Replication, REPLICATION-REPLICATION INHIBITOR complex
Deposited on 2013-04-25, released 2013-05-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-03-26, with a file datestamp of 2014-03-21.
Experiment type: XRAY
Resolution: 2.11 Å
R-factor: 0.223
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HCV Polymerase
    Species: Hepatitis C virus [TaxId:31647]
    Gene: NS5B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26663 (2-End)
      • engineered mutation (48)
      • engineered mutation (102)
      • engineered mutation (115)
      • engineered mutation (317)
    Domains in SCOPe 2.08: d4ke5a_
  • Chain 'B':
    Compound: HCV Polymerase
    Species: Hepatitis C virus [TaxId:31647]
    Gene: NS5B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26663 (2-End)
      • engineered mutation (48)
      • engineered mutation (102)
      • engineered mutation (115)
      • engineered mutation (317)
    Domains in SCOPe 2.08: d4ke5b_
  • Heterogens: 1PV, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ke5A (A:)
masmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsagqrqkkvtfdrlq
vlddhyrdvlkemkakastvkakllsveeackltpphsakskygygakdvrnlssravnh
ihsvwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydv
vstlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirvees
iyqccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylk
asaacraaklqdctmlvygddlvvicesagtqedaaslrvfteamtrysappgdppqpey
dlelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyapt
lwarmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsys
pgeinrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltp
ipaasrldlsgwfvagysggdiyhslsrarprlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4ke5A (A:)
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsagqrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskygygakdvrnlssravnhih
svwkdlledtvtpidttimaknevfcvqprkparlivfpdlgvrvcekmalydvvstlpq
vvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccd
lapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacr
aaklqdctmlvygddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelit
scssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmi
lmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinr
vasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipvagy
sggdiyhs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4ke5B (B:)
masmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsagqrqkkvtfdrlq
vlddhyrdvlkemkakastvkakllsveeackltpphsakskygygakdvrnlssravnh
ihsvwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydv
vstlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirvees
iyqccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylk
asaacraaklqdctmlvygddlvvicesagtqedaaslrvfteamtrysappgdppqpey
dlelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyapt
lwarmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsys
pgeinrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltp
ipaasrldlsgwfvagysggdiyhslsrarprlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4ke5B (B:)
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsagqrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskygygakdvrnlssravnhih
svwkdlledtvtpidttimaknevfcvqpgrkparlivfpdlgvrvcekmalydvvstlp
qvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqcc
dlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaac
raaklqdctmlvygddlvvicesagtqedaaslrvfteamtrysappgdppqpeydleli
tscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarm
ilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgein
rvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipagy
sggdiyh