PDB entry 4kba

View 4kba on RCSB PDB site
Description: CK1d in complex with 9-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-2,3,4,5-tetrahydropyrido[2,3-f][1,4]oxazepine inhibitor
Class: transferase/transferase inhibitor
Keywords: ser/thr kinase, inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2013-04-23, released 2013-09-18
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-09-18, with a file datestamp of 2013-09-13.
Experiment type: XRAY
Resolution: 1.98 Å
R-factor: 0.21
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Casein kinase I isoform delta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1D, HCKID
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4kbaa_
  • Chain 'B':
    Compound: Casein kinase I isoform delta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1D, HCKID
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4kbab_
  • Chain 'C':
    Compound: Casein kinase I isoform delta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1D, HCKID
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4kbac_
  • Chain 'D':
    Compound: Casein kinase I isoform delta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1D, HCKID
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4kbad_
  • Heterogens: 1QM, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4kbaA (A:)
mhhhhhhssglvprgslrvgnryrlgrkigsgsfgdiylgtdiaageevaiklecvktkh
pqlhieskiykmmqggvgiptirwcgaegdynvmvmellgpsledlfnfcsrkfslktvl
lladqmisrieyihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhip
yrenknltgtaryasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkye
risekkmstpievlckgypsefatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydy
vfdwnmlkfgasraaddaererrdreerlrh

    Sequence, based on observed residues (ATOM records): (download) 
    >4kbaA (A:)
lrvgnryrlgrkigsgsfgdiylgtdiaageevaiklecvktkhpqlhieskiykmmqgg
vgiptirwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsk
nfihrdvkpdnflmglgkkgnlvyiidfglakkygtaryasinthlgieqsrrddleslg
yvlmyfnlgslpwqglrisekkmstpievlckgypsefatylnfcrslrfddkpdysylr
qlfrnlfhrqgfsydyvfdwnml

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4kbaB (B:)
mhhhhhhssglvprgslrvgnryrlgrkigsgsfgdiylgtdiaageevaiklecvktkh
pqlhieskiykmmqggvgiptirwcgaegdynvmvmellgpsledlfnfcsrkfslktvl
lladqmisrieyihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhip
yrenknltgtaryasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkye
risekkmstpievlckgypsefatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydy
vfdwnmlkfgasraaddaererrdreerlrh

    Sequence, based on observed residues (ATOM records): (download) 
    >4kbaB (B:)
lrvgnryrlgrkigsgsfgdiylgtdiaageevaiklecqlhieskiykmmqggvgipti
rwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknfihrd
vkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasinthlgi
eqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgypsef
atylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnml

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4kbaC (C:)
mhhhhhhssglvprgslrvgnryrlgrkigsgsfgdiylgtdiaageevaiklecvktkh
pqlhieskiykmmqggvgiptirwcgaegdynvmvmellgpsledlfnfcsrkfslktvl
lladqmisrieyihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhip
yrenknltgtaryasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkye
risekkmstpievlckgypsefatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydy
vfdwnmlkfgasraaddaererrdreerlrh

    Sequence, based on observed residues (ATOM records): (download) 
    >4kbaC (C:)
nryrlgrkigsgsfgdiylgtdiaageevaiklecvktkhpqlhieskiykmmqggvgip
tirwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknfih
rdvkpdnflmglgkkgnlvyiidfglakkyyrenknltgtaryasinthlgieqsrrddl
eslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgypsefatylnfcr
slrfddkpdysylrqlfrnlfhrqgfsydyvfdwnml

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4kbaD (D:)
mhhhhhhssglvprgslrvgnryrlgrkigsgsfgdiylgtdiaageevaiklecvktkh
pqlhieskiykmmqggvgiptirwcgaegdynvmvmellgpsledlfnfcsrkfslktvl
lladqmisrieyihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhip
yrenknltgtaryasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkye
risekkmstpievlckgypsefatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydy
vfdwnmlkfgasraaddaererrdreerlrh

    Sequence, based on observed residues (ATOM records): (download) 
    >4kbaD (D:)
lrvgnryrlgrkigdiylgtdiaageevaiklecpqlhieskiykmmqggvgiptirwcg
aegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknfihrdvkpd
nflmglgkkgnlvyiidfglakkyhipyrenknltgtaryasinthlgieqsrrddlesl
gyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgypsefatylnfcrslr
fddkpdysylrqlfrnlfhrqgfsydyvfdwnml