PDB entry 4k71

View 4k71 on RCSB PDB site
Description: Crystal structure of a high affinity Human Serum Albumin variant bound to the Neonatal Fc Receptor
Class: lipid transport
Keywords: MHC Class I, Lipid Transport, Endosome Recycling, Endosome
Deposited on 2013-04-16, released 2013-10-23
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-02-05, with a file datestamp of 2014-01-31.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.214
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serum albumin
    Species: Homo sapiens [TaxId:9606]
    Gene: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02768 (Start-584)
      • engineered mutation (417)
      • engineered mutation (419)
      • engineered mutation (504)
      • engineered mutation (546)
    Domains in SCOPe 2.07: d4k71a1, d4k71a2, d4k71a3
  • Chain 'B':
    Compound: igg receptor fcrn large subunit p51
    Species: Homo sapiens [TaxId:9606]
    Gene: FCGRT, FCRN
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4k71b1, d4k71b2
  • Chain 'C':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4k71c_
  • Chain 'D':
    Compound: serum albumin
    Species: Homo sapiens [TaxId:9606]
    Gene: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02768 (Start-584)
      • engineered mutation (417)
      • engineered mutation (419)
      • engineered mutation (504)
      • engineered mutation (546)
    Domains in SCOPe 2.07: d4k71d1, d4k71d2, d4k71d3
  • Chain 'E':
    Compound: igg receptor fcrn large subunit p51
    Species: Homo sapiens [TaxId:9606]
    Gene: FCGRT, FCRN
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4k71e1, d4k71e2
  • Chain 'F':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4k71f_
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4k71A (A:)
    dahksevahrfkdlgeenfkalvliafaqylqqcpfedhvklvnevtefaktcvadesae
    ncdkslhtlfgdklctvatlretygemadccakqepernecflqhkddnpnlprlvrpev
    dvmctafhdneetflkkylyeiarrhpyfyapellffakrykaafteccqaadkaacllp
    kldelrdegkassakqrlkcaslqkfgerafkawavarlsqrfpkaefaevsklvtdltk
    vhtecchgdllecaddradlakyicenqdsissklkeccekpllekshciaevendempa
    dlpslaadfveskdvcknyaeakdvflgmflyeyarrhpdysvvlllrlaktyettlekc
    caaadphecyakvfdefkplveepqnlikqncelfeqlgeykfqnallvrytkkvpqmsa
    ptlvevsrnlgkvgskcckhpeakrmpcaedylsvvlnqlcvlhektpvsdrvtkcctes
    lvnrrpcfsalevdetyvpkefnagtftfhadictlsekerqikkqtalvelvkhkpkat
    keqlkaamddfaafvekcckaddketcfaeegkklvaasqaalgl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4k71A (A:)
    hksevahrfkdlgeenfkalvliafaqylqqcpfedhvklvnevtefaktcvadesaenc
    dkslhtlfgdklctvatlretygemadccakqepernecflqhkddnpnlprlvrpevdv
    mctafhdneetflkkylyeiarrhpyfyapellffakrykaafteccqaadkaacllpkl
    delrdegkassakqrlkcaslqkfgerafkawavarlsqrfpkaefaevsklvtdltkvh
    tecchgdllecaddradlakyicenqdsissklkeccekpllekshciaevendempadl
    pslaadfveskdvcknyaeakdvflgmflyeyarrhpdysvvlllrlaktyettlekcca
    aadphecyakvfdefkplveepqnlikqncelfeqlgeykfqnallvrytkkvpqmsapt
    lvevsrnlgkvgskcckhpeakrmpcaedylsvvlnqlcvlhektpvsdrvtkccteslv
    nrrpcfsalevdetyvpkefnagtftfhadictlsekerqikkqtalvelvkhkpkatke
    qlkaamddfaafvekcckaddketcfaeegkklvaasqaalgl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4k71B (B:)
    aeshlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswy
    wekettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnf
    dlkqgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkepp
    smrlkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssl
    tvksgdehhyccivqhaglaqplrvelespakss
    

    Sequence, based on observed residues (ATOM records): (download)
    >4k71B (B:)
    lsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswyweke
    ttdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdlkq
    gtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsmrl
    karpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvks
    gdehhyccivqhaglaqplrvele
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4k71C (C:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4k71D (D:)
    dahksevahrfkdlgeenfkalvliafaqylqqcpfedhvklvnevtefaktcvadesae
    ncdkslhtlfgdklctvatlretygemadccakqepernecflqhkddnpnlprlvrpev
    dvmctafhdneetflkkylyeiarrhpyfyapellffakrykaafteccqaadkaacllp
    kldelrdegkassakqrlkcaslqkfgerafkawavarlsqrfpkaefaevsklvtdltk
    vhtecchgdllecaddradlakyicenqdsissklkeccekpllekshciaevendempa
    dlpslaadfveskdvcknyaeakdvflgmflyeyarrhpdysvvlllrlaktyettlekc
    caaadphecyakvfdefkplveepqnlikqncelfeqlgeykfqnallvrytkkvpqmsa
    ptlvevsrnlgkvgskcckhpeakrmpcaedylsvvlnqlcvlhektpvsdrvtkcctes
    lvnrrpcfsalevdetyvpkefnagtftfhadictlsekerqikkqtalvelvkhkpkat
    keqlkaamddfaafvekcckaddketcfaeegkklvaasqaalgl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4k71D (D:)
    ahksevahrfkdlgeenfkalvliafaqylqqcpfedhvklvnevtefaktcvadesaen
    cdkslhtlfgdklctvatlretygemadccakqepernecflqhkddnpnlprlvrpevd
    vmctafhdneetflkkylyeiarrhpyfyapellffakrykaafteccqaadkaacllpk
    ldelrdegkassakqrlkcaslqkfgerafkawavarlsqrfpkaefaevsklvtdltkv
    htecchgdllecaddradlakyicenqdsissklkeccekpllekshciaevendempad
    lpslaadfveskdvcknyaeakdvflgmflyeyarrhpdysvvlllrlaktyettlekcc
    aaadphecyakvfdefkplveepqnlikqncelfeqlgeykfqnallvrytkkvpqmsap
    tlvevsrnlgkvgskcckhpeakrmpcaedylsvvlnqlcvlhektpvsdrvtkcctesl
    vnrrpcfsalevdetyvpkefnagtftfhadictlsekerqikkqtalvelvkhkpkatk
    eqlkaamddfaafvekccetcfaeegkklvaasqaalgl
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >4k71E (E:)
    aeshlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswy
    wekettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnf
    dlkqgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkepp
    smrlkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssl
    tvksgdehhyccivqhaglaqplrvelespakss
    

    Sequence, based on observed residues (ATOM records): (download)
    >4k71E (E:)
    lsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswyweke
    ttdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdlkq
    gtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsmrl
    karpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvks
    gdehhyccivqhaglaqplrvele
    

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4k71F (F:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm