PDB entry 4k4h

View 4k4h on RCSB PDB site
Description: Ternary crystal structures of a human DNA POLYMERASE LAMBDA IN COMPLEX WITH DNA AND (-)3TC-TP.
Class: transferase/DNA
Keywords: DNA POLYMERASE, DNA REPAIR, PHOSPHORYL TRANSFER REACTION, TRANSFERASE-DNA complex
Deposited on 2013-04-12, released 2014-07-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-08-13, with a file datestamp of 2014-08-08.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.207
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA polymerase lambda
    Species: Homo sapiens [TaxId:9606]
    Gene: POLL
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UGP5 (Start-331)
      • expression tag (332-337)
    Domains in SCOPe 2.07: d4k4ha1, d4k4ha2, d4k4ha3, d4k4ha4
  • Chain 'B':
    Compound: DNA (5'-d(*cp*gp*gp*cp*gp*gp*tp*ap*cp*tp*g)-3')
    Species: Homo sapiens [TaxId:9606]
  • Chain 'C':
    Compound: DNA (5'-d(*cp*ap*gp*tp*ap*c)-3')
    Species: Homo sapiens [TaxId:9606]
  • Chain 'D':
    Compound: DNA (5'-d(p*gp*cp*cp*g)-3')
    Species: Homo sapiens [TaxId:9606]
  • Chain 'E':
    Compound: DNA polymerase lambda
    Species: Homo sapiens [TaxId:9606]
    Gene: POLL
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UGP5 (Start-331)
      • expression tag (332)
    Domains in SCOPe 2.07: d4k4he1, d4k4he2, d4k4he3, d4k4he4
  • Chain 'F':
    Compound: DNA (5'-d(*cp*gp*gp*cp*gp*gp*tp*ap*cp*tp*g)-3')
    Species: Homo sapiens [TaxId:9606]
  • Chain 'G':
    Compound: DNA (5'-d(*cp*ap*gp*tp*ap*c)-3')
    Species: Homo sapiens [TaxId:9606]
  • Chain 'H':
    Compound: DNA (5'-d(p*gp*cp*cp*g)-3')
    Species: Homo sapiens [TaxId:9606]
  • Chain 'I':
    Compound: DNA polymerase lambda
    Species: Homo sapiens [TaxId:9606]
    Gene: POLL
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UGP5 (Start-331)
      • expression tag (332-336)
    Domains in SCOPe 2.07: d4k4hi1, d4k4hi2, d4k4hi3, d4k4hi4
  • Chain 'J':
    Compound: DNA (5'-d(*cp*gp*gp*cp*gp*gp*tp*ap*cp*tp*g)-3')
    Species: Homo sapiens [TaxId:9606]
  • Chain 'K':
    Compound: DNA (5'-d(*cp*ap*gp*tp*ap*c)-3')
    Species: Homo sapiens [TaxId:9606]
  • Chain 'L':
    Compound: DNA (5'-d(p*gp*cp*cp*g)-3')
    Species: Homo sapiens [TaxId:9606]
  • Chain 'M':
    Compound: DNA polymerase lambda
    Species: Homo sapiens [TaxId:9606]
    Gene: POLL
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UGP5 (Start-331)
      • expression tag (332-333)
    Domains in SCOPe 2.07: d4k4hm1, d4k4hm2, d4k4hm3, d4k4hm4
  • Chain 'N':
    Compound: DNA (5'-d(*cp*gp*gp*cp*gp*gp*tp*ap*cp*tp*g)-3')
    Species: Homo sapiens [TaxId:9606]
  • Chain 'O':
    Compound: DNA (5'-d(*cp*ap*gp*tp*ap*c)-3')
    Species: Homo sapiens [TaxId:9606]
  • Chain 'P':
    Compound: DNA (5'-d(p*gp*cp*cp*g)-3')
    Species: Homo sapiens [TaxId:9606]
  • Heterogens: 1RZ, CA, ACT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4k4hA (A:)
    mssqkatnhnlhiteklevlakaysvqgdkwralgyakainalksfhkpvtsyqeacsip
    gigkrmaekiieilesghlrkldhisesvpvlelfsniwgagtktaqmwyqqgfrsledi
    rsqaslttqqaiglkhysdflermpreeateieqtvqkaaqafnsgllcvacgsyrrgka
    tcgdvdvlithpdgrshrgifsrlldslrqegfltddlvsqeengqqqkylgvcrlpgpg
    rrhrrldiivvpysefacallyftgsahfnrsmralaktkgmslsehalstavvrnthgc
    kvgpgrvlptptekdvfrllglpyrepaerdwlehhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4k4hA (A:)
    atnhnlhiteklevlakaysvqgdkwralgyakainalksfhkpvtsyqeacsipgigkr
    maekiieilesghlrkldhisesvpvlelfsniwgagtktaqmwyqqgfrsledirsqas
    lttqqaiglkhysdflermpreeateieqtvqkaaqafnsgllcvacgsyrrgkatcgdv
    dvlithpdgrshrgifsrlldslrqegfltddlvsqeengqqqkylgvcrlpgpgrrhrr
    ldiivvpysefacallyftgsahfnrsmralaktkgmslsehalstavvkvgpgrvlptp
    tekdvfrllglpyrepaerdwlehhhh
    

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >4k4hE (E:)
    mssqkatnhnlhiteklevlakaysvqgdkwralgyakainalksfhkpvtsyqeacsip
    gigkrmaekiieilesghlrkldhisesvpvlelfsniwgagtktaqmwyqqgfrsledi
    rsqaslttqqaiglkhysdflermpreeateieqtvqkaaqafnsgllcvacgsyrrgka
    tcgdvdvlithpdgrshrgifsrlldslrqegfltddlvsqeengqqqkylgvcrlpgpg
    rrhrrldiivvpysefacallyftgsahfnrsmralaktkgmslsehalstavvrnthgc
    kvgpgrvlptptekdvfrllglpyrepaerdwlehhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4k4hE (E:)
    atnhnlhiteklevlakaysvqgdkwralgyakainalksfhkpvtsyqeacsipgigkr
    maekiieilesghlrkldhisesvpvlelfsniwgagtktaqmwyqqgfrsledirsqas
    lttqqaiglkhysdflermpreeateieqtvqkaaqafnsgllcvacgsyrrgkatcgdv
    dvlithpdgrshrgifsrlldslrqegfltddlvsqegqqqkylgvcrlpgpgrrhrrld
    iivvpysefacallyftgsahfnrsmralaktkgmslsehalstavvrnthgckvgpgrv
    lptptekdvfrllglpyrepaerdwl
    

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    Sequence, based on SEQRES records: (download)
    >4k4hI (I:)
    mssqkatnhnlhiteklevlakaysvqgdkwralgyakainalksfhkpvtsyqeacsip
    gigkrmaekiieilesghlrkldhisesvpvlelfsniwgagtktaqmwyqqgfrsledi
    rsqaslttqqaiglkhysdflermpreeateieqtvqkaaqafnsgllcvacgsyrrgka
    tcgdvdvlithpdgrshrgifsrlldslrqegfltddlvsqeengqqqkylgvcrlpgpg
    rrhrrldiivvpysefacallyftgsahfnrsmralaktkgmslsehalstavvrnthgc
    kvgpgrvlptptekdvfrllglpyrepaerdwlehhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4k4hI (I:)
    atnhnlhiteklevlakaysvqgdkwralgyakainalksfhkpvtsyqeacsipgigkr
    maekiieilesghlrkldhisesvpvlelfsniwgagtktaqmwyqqgfrsledirsqas
    lttqqaiglkhysdflermpreeateieqtvqkaaqafnsgllcvacgsyrrgkatcgdv
    dvlithpdgrshrgifsrlldslrqegfltddlvsqeengqqqkylgvcrlpgpgrrhrr
    ldiivvpysefacallyftgsahfnrsmralaktkgmslsehalstavvrnthgckvgpg
    rvlptptekdvfrllglpyrepaerdwlehhh
    

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    No sequence available.

  • Chain 'L':
    No sequence available.

  • Chain 'M':
    Sequence, based on SEQRES records: (download)
    >4k4hM (M:)
    mssqkatnhnlhiteklevlakaysvqgdkwralgyakainalksfhkpvtsyqeacsip
    gigkrmaekiieilesghlrkldhisesvpvlelfsniwgagtktaqmwyqqgfrsledi
    rsqaslttqqaiglkhysdflermpreeateieqtvqkaaqafnsgllcvacgsyrrgka
    tcgdvdvlithpdgrshrgifsrlldslrqegfltddlvsqeengqqqkylgvcrlpgpg
    rrhrrldiivvpysefacallyftgsahfnrsmralaktkgmslsehalstavvrnthgc
    kvgpgrvlptptekdvfrllglpyrepaerdwlehhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4k4hM (M:)
    atnhnlhiteklevlakaysvqgdkwralgyakainalksfhkpvtsyqeacsipgigkr
    maekiieilesghlrkldhisesvpvlelfsniwgagtktaqmwyqqgfrsledirsqas
    lttqqaiglkhysdflermpreeateieqtvqkaaqafnsgllcvacgsyrrgkatcgdv
    dvlithpdgrshrgifsrlldslrqegfltddlvsqeengqqqkylgvcrlpgpgrrhrr
    ldiivvpysefacallyftgsahfnrsmralaktkgmslsehalstavvrckvgpgrvlp
    tptekdvfrllglpyrepaerdwle
    

  • Chain 'N':
    No sequence available.

  • Chain 'O':
    No sequence available.

  • Chain 'P':
    No sequence available.