PDB entry 4jyu

View 4jyu on RCSB PDB site
Description: Structure of factor VIIA in complex with the inhibitor (2R)-2-[(1-AMINOISOQUINOLIN-6-YL)AMINO]-2-[3-ETHOXY-4-(PROPAN-2-YLOXY)PHENYL]-N-(PHENYLSULFONYL)ETHANAMIDE
Class: hydrolase/hydrolase inhibitor
Keywords: GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM-BINDING, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2013-04-01, released 2013-07-24
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-09-11, with a file datestamp of 2013-09-06.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.176
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Factor VII light chain
    Species: Homo sapiens [TaxId:9606]
    Gene: F7
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4jyuh_
  • Chain 'L':
    Compound: Factor VII heavy chain
    Species: Homo sapiens [TaxId:9606]
    Gene: F7
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4jyul_
  • Heterogens: 1OK, CA, SO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4jyuH (H:)
    ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
    lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
    lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
    sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
    seprpgvllrapfp
    

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4jyuL (L:)
    icvnenggceqycsdhtgtkrscrchegyslladgvsctptveypcgkipilekr