PDB entry 4jra

View 4jra on RCSB PDB site
Description: CRYSTAL STRUCTURE OF THE BOTULINUM NEUROTOXIN A RECEPTOR-BINDING DOMAIN IN COMPLEX WITH THE LUMINAL DOMAIN Of SV2C
Class: hydrolase
Keywords: Beta-helix, Vesicles, lumen, toxin, HYDROLASE
Deposited on 2013-03-21, released 2013-11-20
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-02-12, with a file datestamp of 2014-02-07.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.24
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Botulinum neurotoxin type A
    Species: Clostridium botulinum [TaxId:1491]
    Gene: botA, atx, bna
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4jraa1, d4jraa2
  • Chain 'B':
    Compound: Botulinum neurotoxin type A
    Species: Clostridium botulinum [TaxId:1491]
    Gene: botA, atx, bna
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4jrab1, d4jrab2
  • Chain 'C':
    Compound: Synaptic vesicle glycoprotein 2C
    Species: Homo sapiens [TaxId:9606]
    Gene: SV2C, KIAA1054
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Synaptic vesicle glycoprotein 2C
    Species: Homo sapiens [TaxId:9606]
    Gene: SV2C, KIAA1054
    Database cross-references and differences (RAF-indexed):
  • Heterogens: CL, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4jraA (A:)
mkkhhhhhhgslvprgskniintsilnlryesnhlidlsryaskinigskvnfdpidknq
iqlfnlesskievilknaivynsmyenfstsfwiripkyfnsislnneytiincmennsg
wkvslnygeiiwtlqdtqeikqrvvfkysqminisdyinrwifvtitnnrlnnskiying
rlidqkpisnlgnihasnnimfkldgcrdthryiwikyfnlfdkelnekeikdlydnqsn
sgilkdfwgdylqydkpyymlnlydpnkyvdvnnvgirgymylkgprgsvmttniylnss
lyrgtkfiikkyasgnkdnivrnndrvyinvvvknkeyrlatnasqagvekilsaleipd
vgnlsqvvvmkskndqgitnkckmnlqdnngndigfigfhqfnniaklvasnwynrqier
ssrtlgcswefipvddgwgerpl

    Sequence, based on observed residues (ATOM records): (download) 
    >4jraA (A:)
tsilnlryesnhlidlsryaskinigskvnfdpidknqiqlfnlesskievilknaivyn
smyenfstsfwiripkyfnsislnneytiincmennsgwkvslnygeiiwtlqdtqeikq
rvvfkysqminisdyinrwifvtitnnrlnnskiyingrlidqkpisnlgnihasnnimf
kldgcrdthryiwikyfnlfdkelnekeikdlydnqsnsgilkdfwgdylqydkpyymln
lydpnkyvdvnnvgirgymylkgprgsvmttniylnsslyrgtkfiikkyasgdnivrnn
drvyinvvvknkeyrlatnasqagvekilsaleipdvgnlsqvvvmksknitnkckmnlq
dnngndigfigfhqfnniaklvasnwynrqierssrtlgcswefipvddgwgerpl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4jraB (B:)
mkkhhhhhhgslvprgskniintsilnlryesnhlidlsryaskinigskvnfdpidknq
iqlfnlesskievilknaivynsmyenfstsfwiripkyfnsislnneytiincmennsg
wkvslnygeiiwtlqdtqeikqrvvfkysqminisdyinrwifvtitnnrlnnskiying
rlidqkpisnlgnihasnnimfkldgcrdthryiwikyfnlfdkelnekeikdlydnqsn
sgilkdfwgdylqydkpyymlnlydpnkyvdvnnvgirgymylkgprgsvmttniylnss
lyrgtkfiikkyasgnkdnivrnndrvyinvvvknkeyrlatnasqagvekilsaleipd
vgnlsqvvvmkskndqgitnkckmnlqdnngndigfigfhqfnniaklvasnwynrqier
ssrtlgcswefipvddgwgerpl

    Sequence, based on observed residues (ATOM records): (download) 
    >4jraB (B:)
ntsilnlryesnhlidlsryaskinigskvnfdpidknqiqlfnlesskievilknaivy
nsmyenfstsfwiripkyfnsislnneytiincmennsgwkvslnygeiiwtlqdtqeik
qrvvfkysqminisdyinrwifvtitnnrlnnskiyingrlidqkpisnlgnihasnnim
fkldgcrdthryiwikyfnlfdkelnekeikdlydnqsnsgilkdfwgdylqydkpyyml
nlydpnkyvdvnnvgirgymylkgprgsvmttniylnsslyrgtkfiikkyasdnivrnn
drvyinvvvknkeyrlatnasqagvekilsaleipdvgnlsqvvvmkskndqtnkckmnl
qdnngndigfigfhqfnniaklvasnwynrqierlgcswefipvddgwgerpl

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.