PDB entry 4jpz

View 4jpz on RCSB PDB site
Description: Voltage-gated sodium channel 1.2 C-terminal domain in complex with FGF13U and Ca2+/calmodulin
Class: transport protein
Keywords: EF hand and IQ motif, ion channel, membrane, TRANSPORT PROTEIN
Deposited on 2013-03-19, released 2014-04-16
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-12-03, with a file datestamp of 2014-11-28.
Experiment type: XRAY
Resolution: 3.02 Å
R-factor: 0.214
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fibroblast growth factor 13
    Species: Homo sapiens [TaxId:9606]
    Gene: FGF13, FHF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4jpza_
  • Chain 'B':
    Compound: Sodium channel protein type 2 subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: SCN2A, NAC2, SCN2A1, SCN2A2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: calmodulin
    Species: Homo sapiens [TaxId:9606]
    Gene: CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4jpzc_
  • Chain 'E':
    Compound: Fibroblast growth factor 13
    Species: Homo sapiens [TaxId:9606]
    Gene: FGF13, FHF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4jpze_
  • Chain 'H':
    Compound: Sodium channel protein type 2 subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: SCN2A, NAC2, SCN2A1, SCN2A2
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: calmodulin
    Species: Homo sapiens [TaxId:9606]
    Gene: CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4jpzi_
  • Heterogens: CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4jpzA (A:)
    mallrksysepqlkgivtklysrqgyhlqlqadgtidgtkdedstytlfnlipvglrvva
    iqgvqtklylamnsegylytselftpeckfkesvfenyyvtyssmiyrqqqsgrgwylgl
    nkegeimkgnhvkknkpaahflpkplkvamykepslhdltefsrsgsgtptksrsvsgvl
    nggksmshnest
    

    Sequence, based on observed residues (ATOM records): (download)
    >4jpzA (A:)
    pqlkgivtklysrqgyhlqlqadgtidgtkdedstytlfnlipvglrvvaiqgvqtklyl
    amnsegylytselftpeckfkesvfenyyvtyssmiyrqqqsgrgwylglnkegeimkgn
    hvkknkpaahflpkplkvamykepslhd
    

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4jpzC (C:)
    madqlteeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadg
    ngtidfpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltde
    evdemireadidgdgqvnyeefvqmmtak
    

    Sequence, based on observed residues (ATOM records): (download)
    >4jpzC (C:)
    eeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgngtidf
    pefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdeevdemi
    readidgdgqvnyeefvqmmtak
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >4jpzE (E:)
    mallrksysepqlkgivtklysrqgyhlqlqadgtidgtkdedstytlfnlipvglrvva
    iqgvqtklylamnsegylytselftpeckfkesvfenyyvtyssmiyrqqqsgrgwylgl
    nkegeimkgnhvkknkpaahflpkplkvamykepslhdltefsrsgsgtptksrsvsgvl
    nggksmshnest
    

    Sequence, based on observed residues (ATOM records): (download)
    >4jpzE (E:)
    pqlkgivtklysrqgyhlqlqadgtidgtkdedstytlfnlipvglrvvaiqgvqtklyl
    amnsegylytselftpeckfkesvfenyyvtyssmiyrqqqsgrgwylglnkegeimkgn
    hvkknkpaahflpkplkvamykepslhd
    

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    Sequence, based on SEQRES records: (download)
    >4jpzI (I:)
    madqlteeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadg
    ngtidfpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltde
    evdemireadidgdgqvnyeefvqmmtak
    

    Sequence, based on observed residues (ATOM records): (download)
    >4jpzI (I:)
    eeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgngtidf
    pefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdeevdemi
    readidgdgqvnyeefvqmmtak