PDB entry 4jm2

View 4jm2 on RCSB PDB site
Description: Crystal Structure of PGT 135 Fab in Complex with gp120 Core Protein from HIV-1 Strain JR-FL Bound to CD4 and 17b Fab
Class: immune system/viral protein
Keywords: Immunoglobulin Fold, IMMUNE SYSTEM-VIRAL PROTEIN complex
Deposited on 2013-03-13, released 2013-05-29
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-07-17, with a file datestamp of 2013-07-12.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.241
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: PGT 135 Heavy Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4JM2 (0-End)
  • Chain 'B':
    Compound: PGT 135 Light Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4JM2 (0-213)
    Domains in SCOPe 2.06: d4jm2b1, d4jm2b2
  • Chain 'C':
    Compound: 17b Light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4JM2 (0-213)
    Domains in SCOPe 2.06: d4jm2c1, d4jm2c2
  • Chain 'D':
    Compound: 17b Heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4JM2 (0-228)
  • Chain 'E':
    Compound: gp120
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Database cross-references and differences (RAF-indexed):
    • PDB 4JM2 (0-End)
    Domains in SCOPe 2.06: d4jm2e_
  • Chain 'F':
    Compound: T-cell surface glycoprotein cd4
    Species: Homo sapiens [TaxId:9606]
    Gene: CD4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4jm2f1, d4jm2f2
  • Heterogens: PG4, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4jm2B (B:)
    eivmtqspdtlsvspgetvtlscrasqninknlawyqykpgqsprlvifetyskiaafpa
    rfvasgsgteftltinnmqsedvavyycqqyeewprtfgqgtkvdikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrgec
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4jm2C (C:)
    divmtqspatlsvspgeratlscrasesvssdlawyqqkpgqaprlliygastratgvpa
    rfsgsgsgaeftltisslqsedfavyycqqynnwpprytfgqgtrleikrtvaapsvfif
    ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
    ltlskadyekhkvyacevthqglsspvtksfnrg
    

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >4jm2E (E:)
    vtehfnmwknnmveqmqediislwdqslkpcvkltplcvgsgscdtsvitqacpkisfep
    ipihycapagfailkcndktfngkgpcknvstvqcthgirpvvstqlllngslaeeevvi
    rsdnftnnaktiivqlkesveinctrpnnntrpgeiigdirqahcnisrakwndtlkqiv
    iklreqfenktivfnhssggdpeivmhsfncggeffycnstqlfnstwnnntegsnnteg
    ntitlpcrikqiinmwqevgkamyappirgqircssnitgllltrdgginengteifrpg
    ggdmrdnwrselykykvvkie
    

    Sequence, based on observed residues (ATOM records): (download)
    >4jm2E (E:)
    vtehfnmwknnmveqmqediislwdqslkpcvkltplcvgsgscdtsvitqacpkisfep
    ipihycapagfailkcndktfngkgpcknvstvqcthgirpvvstqlllngslaeeevvi
    rsdnftnnaktiivqlkesveinctrpnnntigdirqahcnisrakwndtlkqiviklre
    qfenktivfnhssggdpeivmhsfncggeffycnstqlfnstwnnntegsnntegntitl
    pcrikqiinmwqevgkamyappirgqircssnitgllltrdgginengteifrpgggdmr
    dnwrselykykvvki
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >4jm2F (F:)
    kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
    lwdqgnfpliiknlkiedsdtyicevedqkeevqllvfgltansdthllqgqsltltles
    ppgsspsvqcrsprgkniqggktlsvsqlelqdsgtwtctvlqnqkkvefkidivvlafq
    kasnt
    

    Sequence, based on observed residues (ATOM records): (download)
    >4jm2F (F:)
    kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
    lwdqgnfpliiknlkiedsdtyicevedqkeevqllvfgltansdthllqgqsltltles
    ppgsspsvqcrsprgkniqggktlsvsqlelqdsgtwtctvlqnqkkvefkidiv