PDB entry 4jgh

View 4jgh on RCSB PDB site
Description: Structure of the SOCS2-Elongin BC complex bound to an N-terminal fragment of Cullin5
Class: ligase
Keywords: Cullin-RING E3 ubiquitin ligases, Ubiquitination, Cytosol, ligase
Deposited on 2013-03-01, released 2013-08-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-08-07, with a file datestamp of 2013-08-02.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.225
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: suppressor of cytokine signaling 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CIS2, Homo sapiens, SOCS2, SSI2, STATI2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14508 (6-172)
      • expression tag (0-5)
    Domains in SCOPe 2.08: d4jgha1, d4jgha2, d4jgha3
  • Chain 'B':
    Compound: Transcription elongation factor B polypeptide 2
    Species: Mus musculus [TaxId:10090]
    Gene: Mus musculus, Tceb2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4jghb_
  • Chain 'C':
    Compound: Transcription elongation factor B polypeptide 1
    Species: Mus musculus [TaxId:10090]
    Gene: Mus musculus, Tceb1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P83940 (0-95)
      • see remark 999 (83)
    Domains in SCOPe 2.08: d4jghc_
  • Chain 'D':
    Compound: Cullin-5
    Species: Homo sapiens [TaxId:9606]
    Gene: CUL5, Homo sapiens, VACM1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q93034 (0-376)
      • engineered mutation (331)
      • engineered mutation (335)
      • expression tag (377)
    Domains in SCOPe 2.08: d4jghd1, d4jghd2

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4jghA (A:)
hmdpefqaarlakalrelgqtgwywgsmtvneakeklkeapegtflirdsshsdylltis
vktsagptnlrieyqdgkfrldsiicvksklkqfdsvvhlidyyvqmckdkrtgpeaprn
gtvhlyltkplytsapslqhlcrltinkctgaiwglplptrlkdyleeykfqv

    Sequence, based on observed residues (ATOM records): (download) 
    >4jghA (A:)
hmdpefqaarlakalrelgqtgwywgsmtvneakeklkeapegtflirdsshsdylltis
vktsagptnlrieyqdgkfrldsiicvksklkqfdsvvhlidyyvqmckdgtvhlyltkp
lytsapslqhlcrltinkctgaiwglplptrlkdyleeykfqv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4jghB (B:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppeeqrlykddqllddgktlgec
gftsqtarpqapatvglafraddtfealriepfssppelpdvmkpqdsggsaneqavq

    Sequence, based on observed residues (ATOM records): (download) 
    >4jghB (B:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppeeqrlykddqllddgktlgec
gftsqtarpqapatvglafraddtfealriepfssppelpdvmk

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4jghC (C:)
myvklissdghefivkrehaltsgtikamlsgpgqfaenetnevnfreipshvlskvcmy
ftykvrytnssteipefpiapeiplellmaanfldc

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4jghD (D:)
kgslqfedkwdfmrpivlkllrqesvtkqqwfdlfsdvhavclwddkgpakihqalkedi
lefikqaqarvlshqddtallkayivewrkfftqcdilpkpfcqleitlmgkqgsnkksn
vedsivrklmldtwnesifsniknrlqdsamklvhaerlgeafdsqlvigvresyvnlcs
npedklqiyrdnfekayldsterfyrtqapsylqqngvqnymkyadaklkeeekralryl
etrrecnsvealmeccvnalvtsfketilaecqgmikrneteklhlmfslmdkvpngiep
mlkdleehiisagladmvaaaetittdsekyreqldtlfnrfsklvkeafqddprfltar
dkaykavvndatifklev

    Sequence, based on observed residues (ATOM records): (download) 
    >4jghD (D:)
kgslqfedkwdfmrpivlkllrqesvtkqqwfdlfsdvhavclwddkgpakihqalkedi
lefikqaqarvlshqddtallkayivewrkfftqcdilpkpfcqleitlnvedsivrklm
ldtwnesifsniknrlqdsamklvhaerlgeafdsqlvigvresyvnlcsnpedklqiyr
dnfekayldsterfyrtqapsylqqngvqnymkyadaklkeeekralryletrrecnsve
almeccvnalvtsfketilaecqgmikrneteklhlmfslmdkvpngiepmlkdleehii
sagladmvaaaetittdsekyreqldtlfnrfsklvkeafqddprfltardkaykavvnd
atifklev