PDB entry 4j99

View 4j99 on RCSB PDB site
Description: Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Gain-of-Function K659T Mutation.
Class: transferase
Keywords: Bilobate Protein Kinase Fold, Receptor Tyrosine Kinase, ATP Binding, TRANSFERASE
Deposited on 2013-02-15, released 2013-08-07
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-12-28, with a file datestamp of 2016-12-22.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fibroblast growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BEK, FGFR2, KGFR, KSAM
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21802
      • engineered mutation (46)
      • engineered mutation (214)
    Domains in SCOPe 2.07: d4j99a_
  • Chain 'B':
    Compound: Fibroblast growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BEK, FGFR2, KGFR, KSAM
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21802
      • engineered mutation (46)
      • engineered mutation (214)
    Domains in SCOPe 2.07: d4j99b_
  • Chain 'C':
    Compound: Fibroblast growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BEK, FGFR2, KGFR, KSAM
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21802
      • engineered mutation (46)
      • engineered mutation (214)
    Domains in SCOPe 2.07: d4j99c_
  • Chain 'D':
    Compound: Fibroblast growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BEK, FGFR2, KGFR, KSAM
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21802
      • engineered mutation (46)
      • engineered mutation (214)
    Domains in SCOPe 2.07: d4j99d_
  • Heterogens: SO4, ACP, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4j99A (A:)
    mgsshhhhhhsqdpmlagvseyelpedpkwefprdkltlgkplgegafgqvvmaeavgid
    kdkpkeavtvavkmlkddatekdlsdlvsememmkmigkhkniinllgactqdgplyviv
    eyaskgnlreylrarrppgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcih
    rdlaarnvlvtennvmkiadfglardinnidyyktttngrlpvkwmapealfdrvythqs
    dvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpanctnelymmmrdcwhavp
    sqrptfkqlvedldriltlttnee
    

    Sequence, based on observed residues (ATOM records): (download)
    >4j99A (A:)
    yelpedpkwefprdkltlgkplgegafgqvvmaeavgidkdkpkeavtvavkmlkddate
    kdlsdlvsememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrpqmtf
    kdlvsctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardindyyktngr
    lpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkeghrmdk
    panctnelymmmrdcwhavpsqrptfkqlvedldriltlt
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4j99B (B:)
    mgsshhhhhhsqdpmlagvseyelpedpkwefprdkltlgkplgegafgqvvmaeavgid
    kdkpkeavtvavkmlkddatekdlsdlvsememmkmigkhkniinllgactqdgplyviv
    eyaskgnlreylrarrppgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcih
    rdlaarnvlvtennvmkiadfglardinnidyyktttngrlpvkwmapealfdrvythqs
    dvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpanctnelymmmrdcwhavp
    sqrptfkqlvedldriltlttnee
    

    Sequence, based on observed residues (ATOM records): (download)
    >4j99B (B:)
    elpedpkwefprdkltlgkplgegafgqvvmaeavgidkdkpkeavtvavkmlkddatek
    dlsdlvsememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrppgmey
    sydqmtfkdlvsctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardinn
    idyyktttngrlpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelf
    kllkeghrmdkpanctnelymmmrdcwhavpsqrptfkqlvedldriltlt
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4j99C (C:)
    mgsshhhhhhsqdpmlagvseyelpedpkwefprdkltlgkplgegafgqvvmaeavgid
    kdkpkeavtvavkmlkddatekdlsdlvsememmkmigkhkniinllgactqdgplyviv
    eyaskgnlreylrarrppgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcih
    rdlaarnvlvtennvmkiadfglardinnidyyktttngrlpvkwmapealfdrvythqs
    dvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpanctnelymmmrdcwhavp
    sqrptfkqlvedldriltlttnee
    

    Sequence, based on observed residues (ATOM records): (download)
    >4j99C (C:)
    elpedpkwefprdkltlgkplgegafgqvvmaeavgidkdkpkeavtvavkmlkddatek
    dlsdlvsememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrppgmey
    sydqmtfkdlvsctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardinn
    idyyktttngrlpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelf
    kllkeghrmdkpanctnelymmmrdcwhavpsqrptfkqlvedldriltlt
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4j99D (D:)
    mgsshhhhhhsqdpmlagvseyelpedpkwefprdkltlgkplgegafgqvvmaeavgid
    kdkpkeavtvavkmlkddatekdlsdlvsememmkmigkhkniinllgactqdgplyviv
    eyaskgnlreylrarrppgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcih
    rdlaarnvlvtennvmkiadfglardinnidyyktttngrlpvkwmapealfdrvythqs
    dvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpanctnelymmmrdcwhavp
    sqrptfkqlvedldriltlttnee
    

    Sequence, based on observed residues (ATOM records): (download)
    >4j99D (D:)
    eyelpedpkwefprdkltlgkplgegafgqvvmaeavgidkdkpkeavtvavkmlkddat
    ekdlsdlvsememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrqmtf
    kdlvsctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardinnidyyktg
    rlpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkeghrmd
    kpanctnelymmmrdcwhavpsqrptfkqlvedldriltlt