PDB entry 4j95

View 4j95 on RCSB PDB site
Description: Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome in Space Group C2.
Class: transferase
Keywords: Kinase Domain Fold Consisting of N- and C-lobes, Receptor Tyrosine Kinase, ATP Binding, TRANSFERASE
Deposited on 2013-02-15, released 2013-08-07
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-12-28, with a file datestamp of 2016-12-22.
Experiment type: XRAY
Resolution: 2.38 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fibroblast growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BEK, FGFR2, KGFR, KSAM
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21802
      • engineered mutation (46)
      • engineered mutation (214)
    Domains in SCOPe 2.07: d4j95a_
  • Chain 'B':
    Compound: Fibroblast growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BEK, FGFR2, KGFR, KSAM
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21802
      • engineered mutation (46)
      • engineered mutation (214)
    Domains in SCOPe 2.07: d4j95b_
  • Chain 'C':
    Compound: Fibroblast growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BEK, FGFR2, KGFR, KSAM
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21802
      • engineered mutation (46)
      • engineered mutation (214)
    Domains in SCOPe 2.07: d4j95c_
  • Chain 'D':
    Compound: Fibroblast growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BEK, FGFR2, KGFR, KSAM
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21802
      • engineered mutation (46)
    Domains in SCOPe 2.07: d4j95d_
  • Heterogens: ACP, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4j95A (A:)
    mgsshhhhhhsqdpmlagvseyelpedpkwefprdkltlgkplgegafgqvvmaeavgid
    kdkpkeavtvavkmlkddatekdlsdlvsememmkmigkhkniinllgactqdgplyviv
    eyaskgnlreylrarrppgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcih
    rdlaarnvlvtennvmkiadfglardinnidyyknttngrlpvkwmapealfdrvythqs
    dvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpanctnelymmmrdcwhavp
    sqrptfkqlvedldriltlttnee
    

    Sequence, based on observed residues (ATOM records): (download)
    >4j95A (A:)
    elpedpkwefprdkltlgkplgegafgqvvmaeavgidkdkpkeavtvavkmlkddatek
    dlsdlvsememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrpqmtfk
    dlvsctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardiyyknttngrl
    pvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkeghrmdkp
    anctnelymmmrdcwhavpsqrptfkqlvedldriltlt
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4j95B (B:)
    mgsshhhhhhsqdpmlagvseyelpedpkwefprdkltlgkplgegafgqvvmaeavgid
    kdkpkeavtvavkmlkddatekdlsdlvsememmkmigkhkniinllgactqdgplyviv
    eyaskgnlreylrarrppgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcih
    rdlaarnvlvtennvmkiadfglardinnidyyknttngrlpvkwmapealfdrvythqs
    dvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpanctnelymmmrdcwhavp
    sqrptfkqlvedldriltlttnee
    

    Sequence, based on observed residues (ATOM records): (download)
    >4j95B (B:)
    lpedpkwefprdkltlgkplgegafgqvvmaeavgidkdkpkeavtvavkmlkddatekd
    lsdlvsememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrpqmtfkd
    lvsctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardinnidyyknttn
    grlpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkeghrm
    dkpanctnelymmmrdcwhavpsqrptfkqlvedldriltlt
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4j95C (C:)
    mgsshhhhhhsqdpmlagvseyelpedpkwefprdkltlgkplgegafgqvvmaeavgid
    kdkpkeavtvavkmlkddatekdlsdlvsememmkmigkhkniinllgactqdgplyviv
    eyaskgnlreylrarrppgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcih
    rdlaarnvlvtennvmkiadfglardinnidyyknttngrlpvkwmapealfdrvythqs
    dvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpanctnelymmmrdcwhavp
    sqrptfkqlvedldriltlttnee
    

    Sequence, based on observed residues (ATOM records): (download)
    >4j95C (C:)
    lpedpkwefprdkltlgkplgegafgqvvmaeavgidkdkpkeavtvavkmlkddatekd
    lsdlvsememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrqmtfkdl
    vsctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardinnidyyknttng
    rlpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkeghrmd
    kpanctnelymmmrdcwhavpsqrptfkqlvedldriltlt
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4j95D (D:)
    mgsshhhhhhsqdpmlagvseyelpedpkwefprdkltlgkplgegafgqvvmaeavgid
    kdkpkeavtvavkmlkddatekdlsdlvsememmkmigkhkniinllgactqdgplyviv
    eyaskgnlreylrarrppgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcih
    rdlaarnvlvtennvmkiadfglardinnidyyknttngrlpvkwmapealfdrvythqs
    dvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpanctnelymmmrdcwhavp
    sqrptfkqlvedldriltlttnee
    

    Sequence, based on observed residues (ATOM records): (download)
    >4j95D (D:)
    elpedpkwefprdkltlgkplgegafgqvvmaeavgidkdkpkeavtvavkmlkddatek
    dlsdlvsememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrqmtfkd
    lvsctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardigrlpvkwmape
    alfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpanctnely
    mmmrdcwhavpsqrptfkqlvedldriltlt