PDB entry 4j51

View 4j51 on RCSB PDB site
Description: Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04
Class: hydrolase/hydrolase inhibitor
Keywords: HYDROLASE, TYROSINE PHOSPHATASE, inhibitor design, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2013-02-07, released 2013-07-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-07-24, with a file datestamp of 2013-07-19.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.189
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 22
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN22, PTPN8
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4j51a_
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase non-receptor type 22
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN22, PTPN8
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4j51b_
  • Heterogens: N75, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4j51A (A:)
mgsshhhhhhssglvprgshmasmdqreilqkfldeaqskkitkeefaneflklkrqstk
ykadktypttvaekpknikknrykdilpydysrvelslitsdedssyinanfikgvygpk
ayiatqgplsttlldfwrmiweysvliivmacmeyemgkkkcerywaepgemqlefgpfs
vsceaekrksdyiirtlkvkfnsetrtiyqfhyknwpdhdvpssidpileliwdvrcyqe
ddsvpicihcsagcgrtgvicaidytwmllkdgiipenfsvfsliremrtqrpslvqtqe
qyelvynavlelfkrqmdvirdkhsg

    Sequence, based on observed residues (ATOM records): (download) 
    >4j51A (A:)
mdqreilqkfldeaqskkitkeefaneflklkrqstkykadktypttvaekpknikknry
kdilpydysrvelslitdedssyinanfikgvygpkayiatqgplsttlldfwrmiweys
vliivmacmeyemgkkkcerywaepgemqlefgpfsvsceaekrksdyiirtlkvkfnse
trtiyqfhyknwpdhdvpssidpileliwdvrcyqeddsvpicihcsagcgrtgvicaid
ytwmllkdgiipenfsvfsliremrtqrpslvqtqeqyelvynavlelfkrqmdvirdkh
sg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4j51B (B:)
mgsshhhhhhssglvprgshmasmdqreilqkfldeaqskkitkeefaneflklkrqstk
ykadktypttvaekpknikknrykdilpydysrvelslitsdedssyinanfikgvygpk
ayiatqgplsttlldfwrmiweysvliivmacmeyemgkkkcerywaepgemqlefgpfs
vsceaekrksdyiirtlkvkfnsetrtiyqfhyknwpdhdvpssidpileliwdvrcyqe
ddsvpicihcsagcgrtgvicaidytwmllkdgiipenfsvfsliremrtqrpslvqtqe
qyelvynavlelfkrqmdvirdkhsg

    Sequence, based on observed residues (ATOM records): (download) 
    >4j51B (B:)
mdqreilqkfldeaqskkitkeefaneflklkrqstkykadktypttvaekpknikknry
kdilpydysrvelslitdedssyinanfikgvygpkayiatqgplsttlldfwrmiweys
vliivmacmeyemgkkkcerywaepgemqlefgpfsvsceaekrksdyiirtlkvkfnse
trtiyqfhyknwpdhdvpssidpileliwdvrcyqeddsvpicihcsagcgrtgvicaid
ytwmllkdgiipenfsvfsliremrtqrpslvqtqeqyelvynavlelfkrqmdvirdkh
sg