PDB entry 4j4p

View 4j4p on RCSB PDB site
Description: The complex of human IgE-Fc with two bound Fab fragments
Class: immune system
Keywords: Ig like domain, IMMUNE SYSTEM
Deposited on 2013-02-07, released 2014-03-12
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-04-16, with a file datestamp of 2014-04-11.
Experiment type: XRAY
Resolution: 2.91 Å
R-factor: 0.239
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ig epsilon chain c region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01854
      • engineered mutation (41)
      • engineered mutation (147)
    Domains in SCOPe 2.05: d4j4pa1, d4j4pa2, d4j4pa3
  • Chain 'B':
    Compound: ig epsilon chain c region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01854
      • engineered mutation (41)
      • engineered mutation (147)
    Domains in SCOPe 2.05: d4j4pb1, d4j4pb2, d4j4pb3
  • Chain 'C':
    Compound: Immunoglobulin G Fab Fragment Heavy Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4J4P
  • Chain 'D':
    Compound: Immunoglobulin G Fab Fragment Light Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4J4P
    Domains in SCOPe 2.05: d4j4pd1, d4j4pd2
  • Chain 'H':
    Compound: Immunoglobulin G Fab Fragment Heavy Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4J4P (Start-248)
  • Chain 'L':
    Compound: Immunoglobulin G Fab Fragment Light Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4J4P
    Domains in SCOPe 2.05: d4j4pl1, d4j4pl2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4j4pA (A:)
csrdftpptvkilqsscdggghfpptiqllclvsgytpgtiqitwledgqvmdvdlstas
ttqegelastqseltlsqkhwlsdrtytcqvtyqghtfedstkkcadsnprgvsaylsrp
spfdlfirksptitclvvdlapskgtvqltwsrasgkpvnhstrkeekqrngtltvtstl
pvgtrdwiegetyqcrvthphlpralmrsttktsgpraapevyafatpewpgsrdkrtla
cliqnfmpedisvqwlhnevqlpdarhsttqprktkgsgffvfsrlevtraeweqkdefi
cravheaaspsqtvqravsvnpg

    Sequence, based on observed residues (ATOM records): (download) 
    >4j4pA (A:)
tpptvkilqsscdggghfpptiqllclvsgytpgtiqitwledgqvmdvdlstasttqeg
elastqseltlsqkhwlsdrtytcqvtyqghtfedstkkcadsnprgvsaylsrpspfdl
firksptitclvvdlapskgtvqltwsrasgkpvnhstrkeekqrngtltvtstlpvgtr
dwiegetyqcrvthphlpralmrsttktsgpraapevyafatpewpgsrdkrtlacliqn
fmpedisvqwlhnevqlpdarhsttqprktkgsgffvfsrlevtraeweqkdeficravh
eaaspsqtvqravsv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4j4pB (B:)
csrdftpptvkilqsscdggghfpptiqllclvsgytpgtiqitwledgqvmdvdlstas
ttqegelastqseltlsqkhwlsdrtytcqvtyqghtfedstkkcadsnprgvsaylsrp
spfdlfirksptitclvvdlapskgtvqltwsrasgkpvnhstrkeekqrngtltvtstl
pvgtrdwiegetyqcrvthphlpralmrsttktsgpraapevyafatpewpgsrdkrtla
cliqnfmpedisvqwlhnevqlpdarhsttqprktkgsgffvfsrlevtraeweqkdefi
cravheaaspsqtvqravsvnpg

    Sequence, based on observed residues (ATOM records): (download) 
    >4j4pB (B:)
ftpptvkilqsscdggghfpptiqllclvsgytpgtiqitwledgqvmdvdlstasttqe
gelastqseltlsqkhwlsdrtytcqvtyqghtfedstkkcadsnprgvsaylsrpspfd
lfirksptitclvvdlapskgtvqltwsrasgkpvnhstrkeekqrngtltvtstlpvgt
rdwiegetyqcrvthphlpralmrsttktsgpraapevyafatpewpgsrdkrtlacliq
nfmpedisvqwlhnevqlpdarhsttqprktkgsgffvfsrlevtraeweqkdeficrav
heaaspsqtvqravsvn

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4j4pD (D:)
mdwspllltllahctgswaqsvltqppsasgtpgqrvtiscsgsssnignngvnwyqqvp
gkppklliyyddllpsgvsdrfsgsksgtsaslaisglqsedeadyyceawddsldgvvf
gggtkltvlgqpkaapsvtlfppsseelqankatlvclisdfypgavtvawkadsspvka
gvetttpskqsnnkyaassylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >4j4pD (D:)
aqsvltqppsasgtpgqrvtiscsgsssnignngvnwyqqvpgkppklliyyddllpsgv
sdrfsgsksgtsaslaisglqsedeadyyceawddsldgvvfgggtkltvlgqpkaapsv
tlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaas
sylsltpeqwkshrsyscqvthegstvektvapte

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >4j4pL (L:)
mdwspllltllahctgswaqsvltqppsasgtpgqrvtiscsgsssnignngvnwyqqvp
gkppklliyyddllpsgvsdrfsgsksgtsaslaisglqsedeadyyceawddsldgvvf
gggtkltvlgqpkaapsvtlfppsseelqankatlvclisdfypgavtvawkadsspvka
gvetttpskqsnnkyaassylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >4j4pL (L:)
aqsvltqppsasgtpgqrvtiscsgsssnignngvnwyqqvpgkppklliyyddllpsgv
sdrfsgsksgtsaslaisglqsedeadyyceawddsldgvvfgggtkltvlgqpkaapsv
tlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaas
sylsltpeqwkshrsyscqvthegstvektvapte