PDB entry 4ixc

View 4ixc on RCSB PDB site
Description: Crystal structure of Human Glucokinase in complex with a small molecule activator.
Class: transferase/transferase inhibitor
Keywords: Allosteric Regulation, Binding Sites, Catalytic Domain, Diabetes Mellitus, Type 2, Enzyme Activators, Glucokinase, Hexokinase, Humans, Models, Molecular, Mutation, Protein Conformation, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2013-01-25, released 2013-04-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glucokinase isoform 3
    Species: Homo sapiens [TaxId:9606]
    Gene: GCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35557 (3-End)
      • engineered mutation (17-18)
      • engineered mutation (41-42)
    Domains in SCOPe 2.08: d4ixca1, d4ixca2
  • Heterogens: NA, GLC, 1JD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4ixcA (A:)
    gssnsqveqilaefqlqaadlkkvmrrmqkemdrglrlethaaasvkmlptyvrstpegs
    evgdflsldlggtnfrvmlvkvgegeegqwsvktkhqmysipedamtgtaemlfdyisec
    isdfldkhqmkhkklplgftfsfpvrhedidkgillnwtkgfkasgaegnnvvgllrdai
    krrgdfemdvvamvndtvatmiscyyedhqcevgmivgtgcnacymeemqnvelvegdeg
    rmcvntewgafgdsgeldeflleydrlvdessanpgqqlyekliggkymgelvrlvllrl
    vdenllfhgeaseqlrtrgafetrfvsqvesdtgdrkqiynilstlglrpsttdcdivrr
    acesvstraahmcsaglagvinrmresrsedvmritvgvdgsvyklhpsfkerfhasvrr
    ltpsceitfieseegsgrgaalvsavackkacmlgq
    

    Sequence, based on observed residues (ATOM records): (download)
    >4ixcA (A:)
    nsqveqilaefqlqaadlkkvmrrmqkemdrglrlethaaasvkmlptyvrstpegsevg
    dflsldlggtnfrvmlvkvgegqwsvktkhqmysipedamtgtaemlfdyisecisdfld
    khqmkhkklplgftfsfpvrhedidkgillnwtkgfkasgaegnnvvgllrdaikrrgdf
    emdvvamvndtvatmiscyyedhqcevgmivgtgcnacymeemqnvelvegdegrmcvnt
    ewgafgdsgeldeflleydrlvdessanpgqqlyekliggkymgelvrlvllrlvdenll
    fhgeaseqlrtrgafetrfvsqvesdgdrkqiynilstlglrpsttdcdivrracesvst
    raahmcsaglagvinrmresrsedvmritvgvdgsvyklhpsfkerfhasvrrltpscei
    tfieseegsgrgaalvsavackk