PDB entry 4ixc
View 4ixc on RCSB PDB site
Description: Crystal structure of Human Glucokinase in complex with a small molecule activator.
Class: transferase/transferase inhibitor
Keywords: Allosteric Regulation, Binding Sites, Catalytic Domain, Diabetes Mellitus, Type 2, Enzyme Activators, Glucokinase, Hexokinase, Humans, Models, Molecular, Mutation, Protein Conformation, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2013-01-25, released
2013-04-24
The last revision prior to the SCOPe 2.08 freeze date was dated
2020-07-29, with a file datestamp of
2020-07-04.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.37
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Glucokinase isoform 3
Species: Homo sapiens [TaxId:9606]
Gene: GCK
Database cross-references and differences (RAF-indexed):
- Uniprot P35557 (3-End)
- engineered mutation (17-18)
- engineered mutation (41-42)
Domains in SCOPe 2.08: d4ixca1, d4ixca2 - Heterogens: NA, GLC, 1JD, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4ixcA (A:)
gssnsqveqilaefqlqaadlkkvmrrmqkemdrglrlethaaasvkmlptyvrstpegs
evgdflsldlggtnfrvmlvkvgegeegqwsvktkhqmysipedamtgtaemlfdyisec
isdfldkhqmkhkklplgftfsfpvrhedidkgillnwtkgfkasgaegnnvvgllrdai
krrgdfemdvvamvndtvatmiscyyedhqcevgmivgtgcnacymeemqnvelvegdeg
rmcvntewgafgdsgeldeflleydrlvdessanpgqqlyekliggkymgelvrlvllrl
vdenllfhgeaseqlrtrgafetrfvsqvesdtgdrkqiynilstlglrpsttdcdivrr
acesvstraahmcsaglagvinrmresrsedvmritvgvdgsvyklhpsfkerfhasvrr
ltpsceitfieseegsgrgaalvsavackkacmlgq
Sequence, based on observed residues (ATOM records): (download)
>4ixcA (A:)
nsqveqilaefqlqaadlkkvmrrmqkemdrglrlethaaasvkmlptyvrstpegsevg
dflsldlggtnfrvmlvkvgegqwsvktkhqmysipedamtgtaemlfdyisecisdfld
khqmkhkklplgftfsfpvrhedidkgillnwtkgfkasgaegnnvvgllrdaikrrgdf
emdvvamvndtvatmiscyyedhqcevgmivgtgcnacymeemqnvelvegdegrmcvnt
ewgafgdsgeldeflleydrlvdessanpgqqlyekliggkymgelvrlvllrlvdenll
fhgeaseqlrtrgafetrfvsqvesdgdrkqiynilstlglrpsttdcdivrracesvst
raahmcsaglagvinrmresrsedvmritvgvdgsvyklhpsfkerfhasvrrltpscei
tfieseegsgrgaalvsavackk