PDB entry 4isn
View 4isn on RCSB PDB site
Description: Crystal Structure of Matriptase in complex with its inhibitor HAI-1
Class: hydrolase/hydrolase inhibitor
Keywords: Beta barrel, Serine protease inhibitor, epithelium, hydrolase-hydrolase inhibitor complex
Deposited on
2013-01-16, released
2013-03-06
The last revision prior to the SCOPe 2.03 freeze date was dated
2013-05-15, with a file datestamp of
2013-05-10.
Experiment type: XRAY
Resolution: 2.45 Å
R-factor: 0.212
AEROSPACI score: 0.33
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Suppressor of tumorigenicity 14 protein
Species: Homo sapiens [TaxId:9606]
Gene: PRSS14, SNC19, ST14, TADG15
Database cross-references and differences (RAF-indexed):
- Uniprot Q9Y5Y6 (0-240)
- engineered mutation (157)
Domains in SCOPe 2.03: d4isna_ - Chain 'B':
Compound: Kunitz-type protease inhibitor 1
Species: Homo sapiens [TaxId:9606]
Gene: SPINT1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d4isnb_ - Heterogens: PG4, GSH, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>4isnA (A:)
vvggtdadegewpwqvslhalgqghicgaslispnwlvsaahcyiddrgfrysdptqwta
flglhdqsqrsapgvqerrlkriishpffndftfdydiallelekpaeyssmvrpiclpd
ashvfpagkaiwvtgwghtqyggtgalilqkgeirviqqttcenllpqqitprmmcvgfl
sggvdscqgdsggplssveadgrifqagvvswgdgcaqrnkpgvytrlplfrdwikentg
v
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>4isnB (B:)
qtedyclasnkvgrcrgsfprwyydpteqicksfvyggclgnknnylreeecilacrgvq
gp