PDB entry 4is0

View 4is0 on RCSB PDB site
Description: Structural Insights into Omega-Class Glutathione Transferases: A Snapshot of Enzyme Reduction and Identification of the Non-Catalytic Ligandin Site.
Class: transferase, oxidoreductase
Keywords: GST fold, oxidoreductase, ligand-binding, Cytosol, TRANSFERASE
Deposited on 2013-01-15, released 2013-04-24
The last revision prior to the SCOPe 2.04 freeze date was dated 2013-07-03, with a file datestamp of 2013-06-28.
Experiment type: XRAY
Resolution: 1.72 Å
R-factor: 0.155
AEROSPACI score: 0.58 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glutathione S-transferase omega-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GSTO1, GSTTLP28
    Database cross-references and differences (RAF-indexed):
    • Uniprot P78417 (Start-240)
      • engineered mutation (31)
    Domains in SCOPe 2.04: d4is0a1, d4is0a2
  • Heterogens: SO4, GDS, DTT, 1R4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4is0A (A:)
    msgesarslgkgsappgpvpegsiriysmrfapfaertrlvlkakgirhevininlknkp
    ewffkknpfglvpvlensqgqliyesaitceyldeaypgkkllpddpyekacqkmilelf
    skvpslvgsfirsqnkedyaglkeefrkeftkleevltnkkttffggnsismidyliwpw
    ferleamklnecvdhtpklklwmaamkedptvsalltsekdwqgflelylqnspeacdyg
    l
    

    Sequence, based on observed residues (ATOM records): (download)
    >4is0A (A:)
    esarslgkgsappgpvpegsiriysmrfapfaertrlvlkakgirhevininlknkpewf
    fkknpfglvpvlensqgqliyesaitceyldeaypgkkllpddpyekacqkmilelfskv
    pslvgsfirsqnkedyaglkeefrkeftkleevltnkkttffggnsismidyliwpwfer
    leamklnecvdhtpklklwmaamkedptvsalltsekdwqgflelylqnspeacdygl