PDB entry 4iqw

View 4iqw on RCSB PDB site
Description: Tdt core in complex with inhibitor (2Z,5E)-6-[4-(4-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid and ssDNA
Class: transferase/transferase inhibitor/DNA
Keywords: terminal transferase, TRANSFERASE-TRANSFERASE INHIBITOR-DNA complex
Deposited on 2013-01-13, released 2013-09-04
The last revision prior to the SCOPe 2.04 freeze date was dated 2013-10-09, with a file datestamp of 2013-10-04.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.19
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA nucleotidylexotransferase
    Species: Mus musculus [TaxId:10090]
    Gene: DNTT, TDT
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09838 (Start-352)
      • engineered mutation (268)
    • Uniprot P09838 (353-380)
    Domains in SCOPe 2.04: d4iqwa1, d4iqwa2, d4iqwa3
  • Chain 'C':
    Compound: 5'-d(*gp*cp*cp*g)-3'
  • Heterogens: NA, 1FQ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4iqwA (A:)
hmspspvpgsqnvpapavkkisqyacqrrttlnnynqlftdaldilaendelrenegscl
afmrassvlkslpfpitsmkdtegipclgdkvksiiegiiedgesseakavlnderyksf
klftsvfgvglktaekwfrmgfrtlskiqsdkslrftqmqkagflyyedlvscvnrpeae
avsmlvkeavvtflpdalvtmtggfrrgkmtghdvdflitspeatedeeqqllhkvtdfw
kqqglllycdilestfekfkqpsrkvdaadhfqkcflilkldhgrvhseksgqqegkgwk
airvdlvmcpydrrafallgwtgsrqferdlrryatherkmmldnhalydrtkrvfleae
seeeifahlgldyiepwerna

    Sequence, based on observed residues (ATOM records): (download) 
    >4iqwA (A:)
kisqyacqrrttlnnynqlftdaldilaendelrenegsclafmrassvlkslpfpitsm
kdtegipclgdkvksiiegiiedgesseakavlnderyksfklftsvfgvglktaekwfr
mgfrtlskiqsdkslrftqmqkagflyyedlvscvnrpeaeavsmlvkeavvtflpdalv
tmtggfrrgkmtghdvdflitspeatedeeqqllhkvtdfwkqqglllycdilestfekf
kqpsrkdaadhfqkcflilkldhgrvhsekegkgwkairvdlvmcpydrrafallgwtgs
rqferdlrryatherkmmldnhalydrtkrvfleaeseeeifahlgldyiepwerna

  • Chain 'C':
    No sequence available.