PDB entry 4ioi
View 4ioi on RCSB PDB site
Description: Meditope-enabled trastuzumab in complex with CQFDLSTRRLKC
Class: immune system
Keywords: monoclonal antibody, immune system, cancer immunotherapy
Deposited on
2013-01-07, released
2013-10-09
The last revision prior to the SCOPe 2.03 freeze date was dated
2013-11-06, with a file datestamp of
2013-11-01.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.177
AEROSPACI score: 0.4
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Trastuzumab light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d4ioia1, d4ioia2 - Chain 'B':
Compound: Trastuzumab heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Chain 'C':
Compound: meditope
Database cross-references and differences (RAF-indexed):
- Chain 'E':
Compound: protein l
Species: Finegoldia magna [TaxId:1260]
Database cross-references and differences (RAF-indexed):
- Uniprot Q51918 (3-64)
- expression tag (2)
- engineered mutation (17)
- engineered mutation (38)
- engineered mutation (56-58)
Domains in SCOPe 2.03: d4ioie_ - Chain 'H':
Compound: Immunoglobulin G-binding protein A
Species: Staphylococcus aureus [TaxId:158878]
Gene: spa, SAV0111
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d4ioih_ - Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>4ioiA (A:)
diqmtqspillsasvgdrvtitcrasqdvntavawyqqrtngsprlliysasflysgvps
rfsgsrsgtdftltisslqpediadyycqqhyttpptfgagtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec
- Chain 'B':
No sequence available.
- Chain 'C':
No sequence available.
- Chain 'E':
Sequence, based on SEQRES records: (download)
>4ioiE (E:)
sgsevtikvnlifadgkiqtaefkgtfeeataeayryaallakvngeytadledggnhmn
ikfag
Sequence, based on observed residues (ATOM records): (download)
>4ioiE (E:)
sevtikvnlifadgkiqtaefkgtfeeataeayryaallakvngeytadledggnhmnik
fag
- Chain 'H':
Sequence, based on SEQRES records: (download)
>4ioiH (H:)
sgsynkdqqsafyeilnmpnlneaqrngfiqslkddpsqstnvlgeakklnesqa
Sequence, based on observed residues (ATOM records): (download)
>4ioiH (H:)
synkdqqsafyeilnmpnlneaqrngfiqslkddpsqstnvlgeakklnesqa