PDB entry 4i4f
View 4i4f on RCSB PDB site
Description: Structure of Focal Adhesion Kinase catalytic domain in complex with an allosteric binding pyrazolobenzothiazine compound.
Class: transferase/transferase inhibitor
Keywords: Phosphorylated on tyrosines, localized to focal adhesions, transferase-transferase inhibitor complex
Deposited on
2012-11-27, released
2013-02-06
The last revision prior to the SCOPe 2.08 freeze date was dated
2013-04-24, with a file datestamp of
2013-04-19.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.188
AEROSPACI score: 0.54
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Focal adhesion kinase 1
Species: Homo sapiens [TaxId:9606]
Gene: PTK2, FAK, FAK1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4i4fa_ - Heterogens: IPA, 1BR, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4i4fA (A:)
gamgsstrdyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvr
ekflqealtmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslil
yayqlstalayleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykaskgklp
ikwmapesinfrrftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmpp
ncpptlyslmtkcwaydpsrrprftelkaqlstileeekaq
Sequence, based on observed residues (ATOM records): (download)
>4i4fA (A:)
yeiqrerielgrcigegqfgdvhqgiymspalavaiktcknctsdsvrekflqealtmrq
fdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlstalayl
eskrfvhrdiaarnvlvssndcvklgdfglsklpikwmapesinfrrftsasdvwmfgvc
mweilmhgvkpfqgvknndvigriengerlpmppncpptlyslmtkcwaydpsrrprfte
lkaqlstileeekaq