PDB entry 4i3r

View 4i3r on RCSB PDB site
Description: Crystal structure of the outer domain of HIV-1 gp120 in complex with VRC-PG04 space group P3221
Class: Viral Protein/Immune System
Keywords: Antibody Affinity, Antibody Specificity, Binding Sites, HIV Infections, Antibodies, HIV Envelope Protein gp120, AIDS Vaccines, Amino Acid Sequence, Antigens, Epitopes, HIV Antibodies, CD4, Somatic Mutation, Sequence engineering, Complementarity Determining Regions, Immunoglobulin Fab Fragments, Sera, Viral Protein-Immune System complex
Deposited on 2012-11-26, released 2013-01-09
The last revision prior to the SCOPe 2.04 freeze date was dated 2013-02-13, with a file datestamp of 2013-02-08.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.186
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'G':
    Compound: Outer domain of HIV-1 gp120 (KER2018 OD4.2.2)
    Species: Human immunodeficiency virus [TaxId:12721]
    Database cross-references and differences (RAF-indexed):
    • PDB 4I3R (0-189)
  • Chain 'H':
    Compound: Heavy chain of VRC-PG04 Fab
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4I3R (0-227)
  • Chain 'L':
    Compound: Light chain of VRC-PG04 Fab
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4I3R (0-207)
    Domains in SCOPe 2.04: d4i3rl1, d4i3rl2
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4i3rL (L:)
    eivltqspgtlslspgetaslsctaasyghmtwyqkkpgqppkllifatskrasgipdrf
    sgsqfgkqytltitrmepedfaryycqqleffgqgtrleirrtvaapsvfifppsdeqlk
    sgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltlskady
    ekhkvyacevthqglsspvtksfnrgec