PDB entry 4i2x

View 4i2x on RCSB PDB site
Description: Crystal structure of Signal Regulatory Protein gamma (SIRP-gamma) in complex with FabOX117
Class: immune system
Keywords: Protein-Fab complex, Structural Genomics, Oxford Protein Production Facility, OPPF, Signal Regulatory Protein, CD47, cell surface, IMMUNE SYSTEM
Deposited on 2012-11-23, released 2013-12-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.48 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: FabOX117 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4I2X (0-213)
    Domains in SCOPe 2.08: d4i2xa1, d4i2xa2
  • Chain 'B':
    Compound: FabOX117 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4I2X (0-228)
    Domains in SCOPe 2.08: d4i2xb1, d4i2xb2
  • Chain 'C':
    Compound: FabOX117 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4I2X (0-213)
    Domains in SCOPe 2.08: d4i2xc1, d4i2xc2
  • Chain 'D':
    Compound: FabOX117 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4I2X (0-End)
    Domains in SCOPe 2.08: d4i2xd_
  • Chain 'E':
    Compound: Signal-regulatory protein gamma
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Signal-regulatory protein gamma
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ZN, CL, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4i2xA (A:)
divitqspkfmstsvgdrvsitckasqdvstavawfqqkpgqspklliysasyrytgvpd
rftgsgsgtdftftissvqaedlavyycqqhystpwtfgggtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4i2xB (B:)
evklqqsgpelvkpgasvkisckasgysftsyyihwvkqrpgqglewigwvfpgsgntky
nekfkgkatltadtssstaymqlssltsedsavyfcargnydrawfaywgqgtlvtvsaa
kttppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdl
ytlsssvtvpsstwpsetvtcnvahpasstkvdkkivprdcgkhhhhhh

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4i2xC (C:)
divitqspkfmstsvgdrvsitckasqdvstavawfqqkpgqspklliysasyrytgvpd
rftgsgsgtdftftissvqaedlavyycqqhystpwtfgggtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4i2xD (D:)
evklqqsgpelvkpgasvkisckasgysftsyyihwvkqrpgqglewigwvfpgsgntky
nekfkgkatltadtssstaymqlssltsedsavyfcargnydrawfaywgqgtlvtvsaa
kttppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdl
ytlsssvtvpsstwpsetvtcnvahpasstkvdkkivprdcgkhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4i2xD (D:)
evklqqsgpelvkpgasvkisckasgysftsyyihwvkqrpgqglewigwvfpgsgntky
nekfkgkatltadtssstaymqlssltsedsavyfcargnydrawfaywgqgtlvtvsaa
kttppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdl
ytlsssvtvpsstwpsetvtcnvahpasstkvdkkivpr

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.