PDB entry 4hz5

View 4hz5 on RCSB PDB site
Description: Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity
Class: Isomerase/Isomerase inhibitor
Keywords: ATP-binding, Nucleotide-binding, Topoisomerase, ATP-binding domain, Isomerase-Isomerase inhibitor complex
Deposited on 2012-11-14, released 2013-02-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-02-27, with a file datestamp of 2013-02-22.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.234
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA topoisomerase IV, B subunit
    Species: Enterococcus faecalis [TaxId:226185]
    Gene: parE, EF_1615
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4hz5a_
  • Chain 'B':
    Compound: DNA topoisomerase IV, B subunit
    Species: Enterococcus faecalis [TaxId:226185]
    Gene: parE, EF_1615
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4hz5b_
  • Chain 'C':
    Compound: DNA topoisomerase IV, B subunit
    Species: Enterococcus faecalis [TaxId:226185]
    Gene: parE, EF_1615
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4hz5c_
  • Chain 'D':
    Compound: DNA topoisomerase IV, B subunit
    Species: Enterococcus faecalis [TaxId:226185]
    Gene: parE, EF_1615
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4hz5d_
  • Chain 'E':
    Compound: DNA topoisomerase IV, B subunit
    Species: Enterococcus faecalis [TaxId:226185]
    Gene: parE, EF_1615
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4hz5e_
  • Chain 'F':
    Compound: DNA topoisomerase IV, B subunit
    Species: Enterococcus faecalis [TaxId:226185]
    Gene: parE, EF_1615
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4hz5f_
  • Chain 'G':
    Compound: DNA topoisomerase IV, B subunit
    Species: Enterococcus faecalis [TaxId:226185]
    Gene: parE, EF_1615
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4hz5g_
  • Chain 'H':
    Compound: DNA topoisomerase IV, B subunit
    Species: Enterococcus faecalis [TaxId:226185]
    Gene: parE, EF_1615
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4hz5h_
  • Chain 'J':
    Compound: DNA topoisomerase IV, B subunit
    Species: Enterococcus faecalis [TaxId:226185]
    Gene: parE, EF_1615
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4hz5j_
  • Heterogens: 19Y, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4hz5A (A:)
mgleavrkrpgmyigstdsrglhhlvyeivdnavdealsgygneinvtiqkdnsicvads
grgmptgmhasgiptveviftvlhaggkfgqggyktsgglhgvgasvvnalskwlevhiv
rdgveymerfedggkpvgtlkkigktkkrngtsvtflpddtifsttnfsyeilaerlres
afllkgvkitltdergeepkeevfhyeelehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4hz5A (A:)
gleavrkrpgmyigstdsrglhhlvyeivdnavdealsgygneinvtiqkdnsicvadsg
rgmptgmhasgiptveviftvlhhgvgasvvnalskwlevhivrdgveymerfedggkpv
gtlkkigktkkrngtsvtflpddtifsttnfsyeilaerlresafllkgvkitltderge
epkeevfhyee

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4hz5B (B:)
mgleavrkrpgmyigstdsrglhhlvyeivdnavdealsgygneinvtiqkdnsicvads
grgmptgmhasgiptveviftvlhaggkfgqggyktsgglhgvgasvvnalskwlevhiv
rdgveymerfedggkpvgtlkkigktkkrngtsvtflpddtifsttnfsyeilaerlres
afllkgvkitltdergeepkeevfhyeelehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4hz5B (B:)
gleavrkrpgmyigstdsrglhhlvyeivdnavdealsgygneinvtiqkdnsicvadsg
rgmptgmhasgiptveviftvlhhgvgasvvnalskwlevhivrdgveymerfedggkpv
gtlkkigktkkrngtsvtflpddtifsttnfsyeilaerlresafllkgvkitltderge
epkeevfhye

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4hz5C (C:)
mgleavrkrpgmyigstdsrglhhlvyeivdnavdealsgygneinvtiqkdnsicvads
grgmptgmhasgiptveviftvlhaggkfgqggyktsgglhgvgasvvnalskwlevhiv
rdgveymerfedggkpvgtlkkigktkkrngtsvtflpddtifsttnfsyeilaerlres
afllkgvkitltdergeepkeevfhyeelehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4hz5C (C:)
gleavrkrpgmyigstdsrglhhlvyeivdnavdealsgygneinvtiqkdnsicvadsg
rgmptgmhasgiptveviftvlhhgvgasvvnalskwlevhivrdgveymerfedggkpv
gtlkkigktkkrngtsvtflpddtifsttnfsyeilaerlresafllkgvkitltderge
epkeevfhyee

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4hz5D (D:)
mgleavrkrpgmyigstdsrglhhlvyeivdnavdealsgygneinvtiqkdnsicvads
grgmptgmhasgiptveviftvlhaggkfgqggyktsgglhgvgasvvnalskwlevhiv
rdgveymerfedggkpvgtlkkigktkkrngtsvtflpddtifsttnfsyeilaerlres
afllkgvkitltdergeepkeevfhyeelehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4hz5D (D:)
gleavrkrpgmyigstdsrglhhlvyeivdnavdealsgygneinvtiqkdnsicvadsg
rgmptgmhsgiptveviftvlhhgvgasvvnalskwlevhivrdgveymerfedggkpvg
tlkkigktkkrngtsvtflpddtifsttnfsyeilaerlresafllkgvkitltdergee
pkeevfhyee

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4hz5E (E:)
mgleavrkrpgmyigstdsrglhhlvyeivdnavdealsgygneinvtiqkdnsicvads
grgmptgmhasgiptveviftvlhaggkfgqggyktsgglhgvgasvvnalskwlevhiv
rdgveymerfedggkpvgtlkkigktkkrngtsvtflpddtifsttnfsyeilaerlres
afllkgvkitltdergeepkeevfhyeelehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4hz5E (E:)
gleavrkrpgmyigstdsrglhhlvyeivdnavdealsgygneinvtiqkdnsicvadsg
rgmptgmhasgiptveviftvlhhgvgasvvnalskwlevhivrdgveymerfedggkpv
gtlkkigktkkrngtsvtflpddtifsttnfsyeilaerlresafllkgvkitltderge
epkeevfhyee

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4hz5F (F:)
mgleavrkrpgmyigstdsrglhhlvyeivdnavdealsgygneinvtiqkdnsicvads
grgmptgmhasgiptveviftvlhaggkfgqggyktsgglhgvgasvvnalskwlevhiv
rdgveymerfedggkpvgtlkkigktkkrngtsvtflpddtifsttnfsyeilaerlres
afllkgvkitltdergeepkeevfhyeelehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4hz5F (F:)
gleavrkrpgmyigstdsrglhhlvyeivdnavdealsgygneinvtiqkdnsicvadsg
rgmptgmhasgiptveviftvlhhgvgasvvnalskwlevhivrdgveymerfedggkpv
gtlkkigktkkrngtsvtflpddtifsttnfsyeilaerlresafllkgvkitltderge
epkeevfhyee

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4hz5G (G:)
mgleavrkrpgmyigstdsrglhhlvyeivdnavdealsgygneinvtiqkdnsicvads
grgmptgmhasgiptveviftvlhaggkfgqggyktsgglhgvgasvvnalskwlevhiv
rdgveymerfedggkpvgtlkkigktkkrngtsvtflpddtifsttnfsyeilaerlres
afllkgvkitltdergeepkeevfhyeelehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4hz5G (G:)
gleavrkrpgmyigstdsrglhhlvyeivdnavdealsgygneinvtiqkdnsicvadsg
rgmptgmhasgiptveviftvlhhgvgasvvnalskwlevhivrdgveymerfedggkpv
gtlkkigktkkrngtsvtflpddtifsttnfsyeilaerlresafllkgvkitltderge
epkeevfhye

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4hz5H (H:)
mgleavrkrpgmyigstdsrglhhlvyeivdnavdealsgygneinvtiqkdnsicvads
grgmptgmhasgiptveviftvlhaggkfgqggyktsgglhgvgasvvnalskwlevhiv
rdgveymerfedggkpvgtlkkigktkkrngtsvtflpddtifsttnfsyeilaerlres
afllkgvkitltdergeepkeevfhyeelehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4hz5H (H:)
gleavrkrpgmyigstdsrglhhlvyeivdnavdealsgygneinvtiqkdnsicvadsg
rgmptgmhasgiptveviftvlhhgvgasvvnalskwlevhivrdgveymerfedggkpv
gtlkkigktkkrngtsvtflpddtifsttnfsyeilaerlresafllkgvkitltderge
epkeevfhyee

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >4hz5J (J:)
mgleavrkrpgmyigstdsrglhhlvyeivdnavdealsgygneinvtiqkdnsicvads
grgmptgmhasgiptveviftvlhaggkfgqggyktsgglhgvgasvvnalskwlevhiv
rdgveymerfedggkpvgtlkkigktkkrngtsvtflpddtifsttnfsyeilaerlres
afllkgvkitltdergeepkeevfhyeelehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4hz5J (J:)
gleavrkrpgmyigstdsrglhhlvyeivdnavdealsgygneinvtiqkdnsicvadsg
rgmptgmhasgiptveviftvlhgvgasvvnalskwlevhivrdgeymerfedggkpvgt
lkkigtkngtsvtflpddtifttnfsyeilaerlresafllkgvkitltdergeepkeev
fhyee