PDB entry 4hxw

View 4hxw on RCSB PDB site
Description: Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Class: Isomerase/Isomerase inhibitor
Keywords: ATP-binding, Nucleotide-binding, Topoisomerase, ATP-binding domain, Isomerase-Isomerase inhibitor complex
Deposited on 2012-11-12, released 2013-02-13
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-02-27, with a file datestamp of 2013-02-22.
Experiment type: XRAY
Resolution: 1.69 Å
R-factor: 0.172
AEROSPACI score: 0.57 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA gyrase subunit b
    Species: Enterococcus faecalis [TaxId:226185]
    Gene: EF_0005, gyrB
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q839Z1 (0-206)
      • expression tag (207-209)
    Domains in SCOPe 2.06: d4hxwa1, d4hxwa2
  • Heterogens: 1A0, TBU, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4hxwA (A:)
    gleavrkrpgmyigstsgeglhhlvweivdnsidealagfaksiqviiepddsitviddg
    rgipvgiqaktgrpavetvftvlhaggkfggggykvsgglhgvgssvvnalstsldvrvy
    kdgkvyyqeyrrgavvddlkvieetdrhgttvhfipdpeiftettvydfdklatrvrela
    flnrglhisiedrregqedkkeyhyeglehhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4hxwA (A:)
    gleavrkrpgmyigstsgeglhhlvweivdnsidealagfaksiqviiepddsitviddg
    rgipvgiqaktgrpavetvftvlvgssvvnalstsldvrvykdgkvyyqeyrrgavvddl
    kvieetdrhgttvhfipdpeiftettvydfdklatrvrelaflnrglhisiedrregqed
    kkeyhyegleh