PDB entry 4hxw
View 4hxw on RCSB PDB site
Description: Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Class: Isomerase/Isomerase inhibitor
Keywords: ATP-binding, Nucleotide-binding, Topoisomerase, ATP-binding domain, Isomerase-Isomerase inhibitor complex
Deposited on
2012-11-12, released
2013-02-13
The last revision prior to the SCOPe 2.06 freeze date was dated
2013-02-27, with a file datestamp of
2013-02-22.
Experiment type: XRAY
Resolution: 1.69 Å
R-factor: 0.172
AEROSPACI score: 0.57
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: DNA gyrase subunit b
Species: Enterococcus faecalis [TaxId:226185]
Gene: EF_0005, gyrB
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4hxwa1, d4hxwa2 - Heterogens: 1A0, TBU, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4hxwA (A:)
gleavrkrpgmyigstsgeglhhlvweivdnsidealagfaksiqviiepddsitviddg
rgipvgiqaktgrpavetvftvlhaggkfggggykvsgglhgvgssvvnalstsldvrvy
kdgkvyyqeyrrgavvddlkvieetdrhgttvhfipdpeiftettvydfdklatrvrela
flnrglhisiedrregqedkkeyhyeglehhhhhh
Sequence, based on observed residues (ATOM records): (download)
>4hxwA (A:)
gleavrkrpgmyigstsgeglhhlvweivdnsidealagfaksiqviiepddsitviddg
rgipvgiqaktgrpavetvftvlvgssvvnalstsldvrvykdgkvyyqeyrrgavvddl
kvieetdrhgttvhfipdpeiftettvydfdklatrvrelaflnrglhisiedrregqed
kkeyhyegleh