PDB entry 4hw7
View 4hw7 on RCSB PDB site
Description: Crystal structure of FMS kinase domain with a small molecular inhibitor, PLX647-OME
Class: transferase/transferase inhibitor
Keywords: CSF-1-R, FMS PROTO-ONCOGENE, C-FMS, CD115 antigen, Kinase, ATP-binding, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2012-11-07, released
2013-03-27
The last revision prior to the SCOPe 2.02 freeze date was dated
2013-04-17, with a file datestamp of
2013-04-12.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.222
AEROSPACI score: 0.25
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Macrophage colony-stimulating factor 1 receptor
Species: Homo sapiens [TaxId:9606]
Gene: CSF1R, FMS
Database cross-references and differences (RAF-indexed):
- Uniprot P07333
- engineered mutation (136)
- engineered mutation (253)
- engineered mutation (330)
Domains in SCOPe 2.02: d4hw7a_ - Heterogens: 64M
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4hw7A (A:)
mkkghhhhhhgqkpkyqvrwkiiesyegnsytfidptqlpynekwefprnnlqfgktlga
gafgkvveatafglgkedavlkvavkmlkstahadekealmselkimshlgqhenivnll
gacthggpvlviteyctygdllnflrrkaeamlgpslspgqdpegldkedgrplelrdll
hfssqvaqgmaflaskncihrdvaarnvlltnghvakigdfglardimndsnyivkgnar
lpvkwmapesifdsvytvqsdvwsygillweifslglnpypgilvnskfyklvkdgyqma
qpafapkniysimqacwalepthrptfqqitsflqeqaqedrr
Sequence, based on observed residues (ATOM records): (download)
>4hw7A (A:)
ptqlpynekwefprnnlqfgktlgagafgkvveatafglgkedavlkvavkmlkstahad
ekealmselkimshlgqhenivnllgacthggpvlviteyctygdllnflrrkaeamlgp
sgrplelrdllhfssqvaqgmaflaskncihrdvaarnvlltnghvakigdfglardimn
dsnyivkgnarlpvkwmapesifdsvytvqsdvwsygillweifslglnpypgilvnskf
yklvkdgyqmaqpafapkniysimqacwalepthrptfqqitsflqeqa