PDB entry 4hpx

View 4hpx on RCSB PDB site
Description: Crystal structure of Tryptophan Synthase at 1.65 A resolution in complex with alpha aminoacrylate E(A-A) and benzimidazole in the beta site and the F9 inhibitor in the alpha site
Class: lyase/lyase inhibitor
Keywords: Lyase, carbon-oxygen lyase, tryptophan biosynthesis, Salmonella, F9F, benzimidazole, allosteric enzyme, Amino-acid biosynthesis, aromatic amino acid biosynthesis, pyridoxal phosphate, alpha amino acrylate, LYASE-LYASE INHIBITOR complex
Deposited on 2012-10-24, released 2013-12-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-01-01, with a file datestamp of 2013-12-27.
Experiment type: XRAY
Resolution: 1.65 Å
R-factor: 0.144
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: tryptophan synthase alpha chain
    Species: Salmonella enterica subsp. enterica serovar Typhimurium [TaxId:90371]
    Gene: STM1727, trpA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4hpxa_
  • Chain 'B':
    Compound: tryptophan synthase beta chain
    Species: Salmonella enterica subsp. enterica serovar Typhimurium [TaxId:90371]
    Gene: STM1726, trpB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4hpxb_
  • Heterogens: F9F, PEG, BZI, 0JO, BCN, CS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4hpxA (A:)
meryenlfaqlndrregafvpfvtlgdpgieqslkiidtlidagadalelgvpfsdplad
gptiqnanlrafaagvtpaqcfemlalirekhptipigllmyanlvfnngidafyarceq
vgvdsvlvadvpveesapfrqaalrhniapificppnadddllrqvasygrgytyllsrs
gvtgaenrgalplhhlieklkeyhaapalqgfgisspeqvsaavragaagaisgsaivki
ieknlaspkqmlaelrsfvsamkaasra

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4hpxB (B:)
mttllnpyfgefggmyvpqilmpalnqleeafvsaqkdpefqaqfadllknyagrptalt
kcqnitagtrttlylkredllhggahktnqvlgqallakrmgkseiiaetgagqhgvasa
lasallglkcriymgakdverqspnvfrmrlmgaevipvhsgsatlkdacnealrdwsgs
yetahymlgtaagphpyptivrefqrmigeetkaqildkegrlpdaviacvgggsnaigm
fadfindtsvgligvepgghgietgehgaplkhgrvgiyfgmkapmmqtadgqieesysi
sagldfpsvgpqhaylnsigradyvsitddealeafktlcrhegiipalesshalahalk
mmreqpekeqllvvnlsgrgdkdiftvhdilkargei

    Sequence, based on observed residues (ATOM records): (download) 
    >4hpxB (B:)
ttllnpyfgefggmyvpqilmpalnqleeafvsaqkdpefqaqfadllknyagrptaltk
cqnitagtrttlylkredllhggahktnqvlgqallakrmgkseiiaetgagqhgvasal
asallglkcriymgakdverqspnvfrmrlmgaevipvhsgsatlkdacnealrdwsgsy
etahymlgtaagphpyptivrefqrmigeetkaqildkegrlpdaviacvgggsnaigmf
adfindtsvgligvepgghgietgehgaplkhgrvgiyfgmkapmmqtadgqieesysis
agldfpsvgpqhaylnsigradyvsitddealeafktlcrhegiipalesshalahalkm
mreqpekeqllvvnlsgrgdkdiftvhdilkarge