PDB entry 4hcx

View 4hcx on RCSB PDB site
Description: Structure of ICDH-1 from M.tuberculosis complexed with NADPH & Mn2+
Class: oxidoreductase
Keywords: ICDH-1, Rossmann Fold, Dehydrogenase, NADP Binding, OXIDOREDUCTASE
Deposited on 2012-10-01, released 2013-02-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-04-18, with a file datestamp of 2018-04-13.
Experiment type: XRAY
Resolution: 2.18 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Isocitrate dehydrogenase [NADP]
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: icd, Rv3339c, MT3442, MTV016.39c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4hcxa_
  • Chain 'B':
    Compound: Isocitrate dehydrogenase [NADP]
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: icd, Rv3339c, MT3442, MTV016.39c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4hcxb_
  • Heterogens: MN, NDP, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4hcxA (A:)
msnapkikvsgpvveldgdemtrviwklikdmlilpyldirldyydlgiehrdatddqvt
idaayaikkhgvgvkcatitpdearveefnlkkmwlspngtirnilggtifrepivisnv
prlvpgwtkpivigrhafgdqyratnfkvdqpgtvtltftpadgsapivhemvsipedgg
vvlgmynfkesirdfarasfsyglnakwpvylstkntilkaydgmfkdefervyeeefka
qfeaagltyehrliddmvaaclkweggyvwacknydgdvqsdtvaqgygslglmtsvlmt
adgktveaeaahgtvtrhyrqyqagkptstnpiasifawtrglqhrgkldgtpevidfah
klesvviatvesgkmtkdlailigpeqdwlnseefldaiadnlekelan

    Sequence, based on observed residues (ATOM records): (download) 
    >4hcxA (A:)
pkikvsgpvveldgdemtrviwklikdmlilpyldirldyydlgiehrdatddqvtidaa
yaikkhgvgvkcatitpdearveefnlkkmwlspngtirnilggtifrepivisnvprlv
pgwtkpivigrhafgdqyratnfkvdqpgtvtltftpadgsapivhemvsipedggvvlg
mynfkesirdfarasfsyglnakwpvylstkntilkaydgmfkdefervyeeefkaqfea
agltyehrliddmvaaclkweggyvwacknydgdvqsdtvaqgygslglmtsvlmtadgk
tveaeaahgtvtrhyrqyqagkptstnpiasifawtrglqhrgkldgtpevidfahkles
vviatvesgkmtkdlailigpeqdwlnseefldaiadnleke

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4hcxB (B:)
msnapkikvsgpvveldgdemtrviwklikdmlilpyldirldyydlgiehrdatddqvt
idaayaikkhgvgvkcatitpdearveefnlkkmwlspngtirnilggtifrepivisnv
prlvpgwtkpivigrhafgdqyratnfkvdqpgtvtltftpadgsapivhemvsipedgg
vvlgmynfkesirdfarasfsyglnakwpvylstkntilkaydgmfkdefervyeeefka
qfeaagltyehrliddmvaaclkweggyvwacknydgdvqsdtvaqgygslglmtsvlmt
adgktveaeaahgtvtrhyrqyqagkptstnpiasifawtrglqhrgkldgtpevidfah
klesvviatvesgkmtkdlailigpeqdwlnseefldaiadnlekelan

    Sequence, based on observed residues (ATOM records): (download) 
    >4hcxB (B:)
pkikvsgpvveldgdemtrviwklikdmlilpyldirldyydlgiehrdatddqvtidaa
yaikkhgvgvkcatitpdearveefnlkkmwlspngtirnilggtifrepivisnvprlv
pgwtkpivigrhafgdqyratnfkvdqpgtvtltftpadgsapivhemvsipedggvvlg
mynfkesirdfarasfsyglnakwpvylstkntilkaydgmfkdefervyeeefkaqfea
agltyehrliddmvaaclkweggyvwacknydgdvqsdtvaqgygslglmtsvlmtadgk
tveaeaahgtvtrhyrqyqagkptstnpiasifawtrglqhrgkldgtpevidfahkles
vviatvesgkmtkdlailigpeqdwlnseefldaiadnleke