PDB entry 4hby

View 4hby on RCSB PDB site
Description: Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand
Class: signaling protein/inhibitor
Keywords: BROMODOMAIN,CAP, HUNK1, MCAP, MITOTIC CHROMOSOME ASSOCIATED PROTEIN, CELL CYCLE, STRUCTURAL GENOMICS CONSORTIUM, SGC, SIGNALING PROTEIN-INHIBITOR complex
Deposited on 2012-09-28, released 2012-10-31
The last revision prior to the SCOPe 2.07 freeze date was dated 2012-12-12, with a file datestamp of 2012-12-07.
Experiment type: XRAY
Resolution: 1.59 Å
R-factor: 0.188
AEROSPACI score: 0.6 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Bromodomain-containing protein 4
  Species: Homo sapiens [TaxId:9606]
  Gene: BRD4, HUNK1
  Database cross-references and differences (RAF-indexed):
  • Uniprot O60885 (0-126)
    • cloning artifact (1)
  Domains in SCOPe 2.07: d4hbya_
• Heterogens: 13F, EDO, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4hbyA (A:)
  smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
  ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
  nelptee