PDB entry 4hbx

View 4hbx on RCSB PDB site
Description: Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand
Class: protein binding/inhibitor
Keywords: bromodomain,cap, hunk1, mcap, protein binding-inhibitor complex, mitotic chromosome associated protein, cell cycle, structural genomics consortium, sgc
Deposited on 2012-09-28, released 2012-10-31
The last revision prior to the SCOPe 2.07 freeze date was dated 2012-12-12, with a file datestamp of 2012-12-07.
Experiment type: XRAY
Resolution: 1.62 Å
R-factor: 0.179
AEROSPACI score: 0.6 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885 (0-126)
      • conflict (1)
    Domains in SCOPe 2.07: d4hbxa_
  • Heterogens: 14X, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4hbxA (A:)