PDB entry 4hbu

View 4hbu on RCSB PDB site
Description: Crystal structure of CTX-M-15 extended-spectrum beta-lactamase in complex with avibactam (NXL104)
Class: hydrolase/hydrolase inhibitor
Keywords: Hydrolysis of beta-lactams, Antibiotic resistance, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2012-09-28, released 2013-04-10
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-06-03, with a file datestamp of 2015-05-29.
Experiment type: XRAY
Resolution: 1.1 Å
R-factor: N/A
AEROSPACI score: 0.73 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-lactamase
    Species: Escherichia coli [TaxId:562]
    Gene: blaUOE-1, bla, bla CTX-M-15, blaCTX-M-15, blaCTX-M15, CTX-M-15
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4hbua_
  • Heterogens: NXL, EDO, CL, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4hbuA (A:)
    qtadvqqklaelerqsggrlgvalintadnsqilyraderfamcstskvmaaaavlkkse
    sepnllnqrveikksdlvnynpiaekhvngtmslaelsaaalqysdnvamnkliahvggp
    asvtafarqlgdetfrldrteptlntaipgdprdttspramaqtlrnltlgkalgdsqra
    qlvtwmkgnttgaasiqaglpaswvvgdktgsggygttndiaviwpkdraplilvtyftq
    pqpkaesrrdvlasaakivtdgl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4hbuA (A:)
    advqqklaelerqsggrlgvalintadnsqilyraderfamcstskvmaaaavlkksese
    pnllnqrveikksdlvnynpiaekhvngtmslaelsaaalqysdnvamnkliahvggpas
    vtafarqlgdetfrldrteptlntaipgdprdttspramaqtlrnltlgkalgdsqraql
    vtwmkgnttgaasiqaglpaswvvgdktgsggygttndiaviwpkdraplilvtyftqpq
    pkaesrrdvlasaakivtdgl