PDB entry 4hb4

View 4hb4 on RCSB PDB site
Description: Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(537DLTVK541/GLCEQ)-Ran-RanBP1
Class: protein transport/antibiotic
Keywords: HEAT repeat, nuclear export, Ran-RanBP1, LMB, leptomycin B, PROTEIN TRANSPORT-ANTIBIOTIC complex
Deposited on 2012-09-27, released 2013-01-09
The last revision prior to the SCOPe 2.04 freeze date was dated 2013-02-06, with a file datestamp of 2013-02-01.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: 0.189
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTP-binding nuclear protein ran
    Species: Homo sapiens [TaxId:9606]
    Gene: RAN, ARA24, OK/SW-cl.81
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4hb4a_
  • Chain 'B':
    Compound: Ran-specific GTPase-activating protein 1
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: YRB1, CST20, HTN1, SFO1, YDR002W, YD8119.08
    Database cross-references and differences (RAF-indexed):
    • Uniprot P41920
      • conflict (36)
    Domains in SCOPe 2.04: d4hb4b_
  • Chain 'C':
    Compound: Exportin-1
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: CRM1, KAP124, XPO1, YGR218W, G8514
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30822 (2-377)
      • expression tag (0-1)
    • Uniprot P30822 (378-End)
      • engineered mutation (501)
      • engineered mutation (503-505)
      • engineered mutation (986)
  • Heterogens: GNP, MG, EDO, LMB, GOL, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4hb4A (A:)
    maaqgepqvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpik
    fnvwdtagqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlc
    gnkvdikdrkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvamp
    alappevvmdpalaaqyehdlevaqttalpdedddl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4hb4A (A:)
    qvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpikfnvwdta
    gqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlcgnkvdik
    drkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvampalappev
    vmdpalaaqyehdlevaqttalpdedddl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4hb4B (B:)
    dihfepvvhlekvdvktmeedeevlykvraklfrfdkdakewkergtgdckflknkktnk
    vrilmrrdktlkicanhiiapeytlkpnvgsdrswvyactadiaegeaeaftfairfgsk
    enadkfkeefekaqeinkka
    

    Sequence, based on observed residues (ATOM records): (download)
    >4hb4B (B:)
    eedeevlykvraklfrfdkdakewkergtgdckflknkktnkvrilmrrdktlkicanhi
    iapeytlkpnvgsdrswvyactadiaegeaeaftfairfgskenadkfkeefekaqeink
    k
    

  • Chain 'C':
    No sequence available.