PDB entry 4h8w

View 4h8w on RCSB PDB site
Description: Crystal structure of non-neutralizing and ADCC-potent antibody N5-i5 in complex with HIV-1 clade A/E gp120 and sCD4.
Class: viral protein/immune system
Keywords: HIV-1 GP120, CLADE A/E 93TH057, VIRAL PROTEIN, VIRAL PROTEIN-IMMUNE SYSTEM complex
Deposited on 2012-09-24, released 2014-04-09
The last revision prior to the SCOPe 2.04 freeze date was dated 2014-04-09, with a file datestamp of 2014-04-04.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: 0.184
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'C':
    Compound: T-cell surface glycoprotein cd4
    Species: Homo sapiens [TaxId:9606]
    Gene: CD4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4h8wc1, d4h8wc2
  • Chain 'G':
    Compound: hiv-1 clade a/e 93th057 (h375s) gp120
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4H8W (0-352)
  • Chain 'H':
    Compound: Fab heavy chain of ADCC and non-neutralizing anti-HIV-1 antibody N5-i5
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4H8W (0-End)
  • Chain 'L':
    Compound: Fab light chain of ADCC and non-neutralizing anti-HIV-1 antibody N5-i5
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4H8W
    Domains in SCOPe 2.04: d4h8wl1, d4h8wl2
  • Heterogens: NAG, MRD, GOL, HOH

PDB Chain Sequences:

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4h8wC (C:)
    kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
    lwdqgnfpliiknlkiedsdtyicevedqkeevqllvfgltansdthllqgqsltltles
    ppgsspsvqcrsprgkniqggktlsvsqlelqdsgtwtctvlqnqkkvefkidivvlafq
    kasnt
    

    Sequence, based on observed residues (ATOM records): (download)
    >4h8wC (C:)
    kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
    lwdqgnfpliiknlkiedsdtyicevedqkeevqllvfgltansdthllqgqsltltles
    ppgsspsvqcrsprgkniqggktlsvsqlelqdsgtwtctvlqnqkkvefkidivv
    

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >4h8wL (L:)
    qsaltqpasvsgspgqsitisctgtssdvgsynfvswyqqhpgkapklmiyevserpsgi
    snrfsgsksgntasltisglqaedeadyycssyagsttfrvfgggtkltvrgqpkaapsv
    tlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaas
    sylsltpeqwkshrsyscqvthegstvektvaptecs
    

    Sequence, based on observed residues (ATOM records): (download)
    >4h8wL (L:)
    saltqpasvsgspgqsitisctgtssdvgsynfvswyqqhpgkapklmiyevserpsgis
    nrfsgsksgntasltisglqaedeadyycssyagsttfrvfgggtkltvrgqpkaapsvt
    lfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaass
    ylsltpeqwkshrsyscqvthegstvektvap