PDB entry 4h49
View 4h49 on RCSB PDB site
Description: Crystal structure of the catalytic domain of MMP-12 in complex with a twin inhibitor.
Class: hydrolase/hydrolase inhibitor
Keywords: divalent inhibitor, carboxylic twin inhibitor, Dimerisation, METZINCIN, Zinc protease, hydrolase-hydrolase inhibitor complex
Deposited on
2012-09-17, released
2013-04-24
The last revision prior to the SCOPe 2.08 freeze date was dated
2015-08-12, with a file datestamp of
2015-08-07.
Experiment type: XRAY
Resolution: 2.16 Å
R-factor: N/A
AEROSPACI score: 0.27
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Macrophage metalloelastase
Species: Homo sapiens [TaxId:9606]
Gene: HME, MMP12
Database cross-references and differences (RAF-indexed):
- Uniprot P39900 (1-158)
- expression tag (0)
- engineered mutation (66)
Domains in SCOPe 2.08: d4h49a1, d4h49a2 - Chain 'B':
Compound: Macrophage metalloelastase
Species: Homo sapiens [TaxId:9606]
Gene: HME, MMP12
Database cross-references and differences (RAF-indexed):
- Uniprot P39900 (1-158)
- expression tag (0)
- engineered mutation (66)
Domains in SCOPe 2.08: d4h49b1, d4h49b2 - Chain 'C':
Compound: Macrophage metalloelastase
Species: Homo sapiens [TaxId:9606]
Gene: HME, MMP12
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4h49c_ - Chain 'D':
Compound: Macrophage metalloelastase
Species: Homo sapiens [TaxId:9606]
Gene: HME, MMP12
Database cross-references and differences (RAF-indexed):
- Uniprot P39900 (1-158)
- expression tag (0)
- engineered mutation (66)
Domains in SCOPe 2.08: d4h49d1, d4h49d2 - Heterogens: ZN, CA, PGO, DMS, PEG, L29, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>4h49A (A:)
mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
rgahgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavheighsl
glghssdpkavmfptykyvdintfrlsaddirgiqslyg
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>4h49B (B:)
mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
rgahgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavheighsl
glghssdpkavmfptykyvdintfrlsaddirgiqslyg
- Chain 'C':
Sequence, based on SEQRES records: (download)
>4h49C (C:)
mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
rgahgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavheighsl
glghssdpkavmfptykyvdintfrlsaddirgiqslyg
Sequence, based on observed residues (ATOM records): (download)
>4h49C (C:)
vwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfarga
hgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavheighslglg
hssdpkavmfptykyvdintfrlsaddirgiqslyg
- Chain 'D':
Sequence; same for both SEQRES and ATOM records: (download)
>4h49D (D:)
mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
rgahgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavheighsl
glghssdpkavmfptykyvdintfrlsaddirgiqslyg