PDB entry 4grw
View 4grw on RCSB PDB site
Description: Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs)
Class: immune system
Keywords: Cytokine, immunoglobulin fold, VHH domain, IMMUNE SYSTEM
Deposited on
2012-08-27, released
2014-02-19
The last revision prior to the SCOPe 2.04 freeze date was dated
2014-02-19, with a file datestamp of
2014-02-14.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: 0.184
AEROSPACI score: 0.26
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Interleukin-23 subunit alpha
Species: Homo sapiens [TaxId:9606]
Gene: IL23 p19, IL23A, SGRF, UNQ2498/PRO5798
Database cross-references and differences (RAF-indexed):
- Chain 'B':
Compound: Interleukin-12 subunit beta
Species: Homo sapiens [TaxId:9606]
Gene: IL12 p40, IL12B, NKSF2
Database cross-references and differences (RAF-indexed):
- Chain 'C':
Compound: Interleukin-23 subunit alpha
Species: Homo sapiens [TaxId:9606]
Gene: IL23 p19, IL23A, SGRF, UNQ2498/PRO5798
Database cross-references and differences (RAF-indexed):
- Chain 'D':
Compound: Interleukin-12 subunit beta
Species: Homo sapiens [TaxId:9606]
Gene: IL12 p40, IL12B, NKSF2
Database cross-references and differences (RAF-indexed):
- Chain 'E':
Compound: Nanobody 124C4
Species: Llama Glama [TaxId:9844]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d4grwe_ - Chain 'F':
Compound: Nanobody 37D5
Species: Llama Glama [TaxId:9844]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d4grwf_ - Chain 'G':
Compound: Nanobody 124C4
Species: Llama Glama [TaxId:9844]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d4grwg_ - Chain 'H':
Compound: Nanobody 22E11
Species: Llama Glama [TaxId:9844]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d4grwh_ - Chain 'I':
Compound: Nanobody 22E11
Species: Llama Glama [TaxId:9844]
Database cross-references and differences (RAF-indexed):
- Chain 'J':
Compound: Nanobody 37D5
Species: Llama Glama [TaxId:9844]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d4grwj_ - Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
No sequence available.
- Chain 'B':
No sequence available.
- Chain 'C':
No sequence available.
- Chain 'D':
No sequence available.
- Chain 'E':
Sequence; same for both SEQRES and ATOM records: (download)
>4grwE (E:)
evqlvesggglvqpggslrlscaasgftlddyaiawfrqapgkeregvsgidsgdgsayy
adsvkgrftissdnakntvylqmnslrpedtavyycarvrtgwglnapdyamdywgkgtl
vtvss
- Chain 'F':
Sequence, based on SEQRES records: (download)
>4grwF (F:)
evqlvesggglvqpggslrlscaasgftldylaigwfrqapgkeregvscvsssgqytyy
adsvkgrftisrdnaestvylqmnslkpedtavyycatdpecyrvrgyyngeydywgqgt
qvtvss
Sequence, based on observed residues (ATOM records): (download)
>4grwF (F:)
vqlvesggglvqpggslrlscaasgftldylaigwfrqapgkeregvscvsssgqytyya
dsvkgrftisrdnaestvylqmnslkpedtavyycatdpecyrvrgyyngeydywgqgtq
vtvss
- Chain 'G':
Sequence; same for both SEQRES and ATOM records: (download)
>4grwG (G:)
evqlvesggglvqpggslrlscaasgftlddyaiawfrqapgkeregvsgidsgdgsayy
adsvkgrftissdnakntvylqmnslrpedtavyycarvrtgwglnapdyamdywgkgtl
vtvss
- Chain 'H':
Sequence; same for both SEQRES and ATOM records: (download)
>4grwH (H:)
evqlvesggglvqaggslrlscaasgrtfswsavgwfrqapgkerefvaairwsggspyy
adsvkdrftisrdnakntvylqmnslrpedtavylcgetslfptsrgshydtwgqgtqvt
vss
- Chain 'I':
No sequence available.
- Chain 'J':
Sequence, based on SEQRES records: (download)
>4grwJ (J:)
evqlvesggglvqpggslrlscaasgftldylaigwfrqapgkeregvscvsssgqytyy
adsvkgrftisrdnaestvylqmnslkpedtavyycatdpecyrvrgyyngeydywgqgt
qvtvss
Sequence, based on observed residues (ATOM records): (download)
>4grwJ (J:)
qlvesggglvqpggslrlscaasgftldylaigwfrqapgkeregvscvsssgqytyyad
svkgrftisrdnaestvylqmnslkpedtavyycatdpecyrvrgyyngdywgqgtqvtv
ss