PDB entry 4gpt

View 4gpt on RCSB PDB site
Description: Crystal structure of KPT251 in complex with CRM1-Ran-RanBP1
Class: protein transport/inhibitor
Keywords: HEAT repeat, protein nuclear export, KPT251, nuclear, PROTEIN TRANSPORT-INHIBITOR complex
Deposited on 2012-08-21, released 2012-09-05
The last revision prior to the SCOPe 2.04 freeze date was dated 2013-01-23, with a file datestamp of 2013-01-18.
Experiment type: XRAY
Resolution: 2.22 Å
R-factor: 0.167
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTP-binding nuclear protein ran
    Species: Homo sapiens [TaxId:9606]
    Gene: RAN, ARA24, OK/SW-cl.81
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4gpta_
  • Chain 'B':
    Compound: Ran-specific GTPase-activating protein 1
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: YRB1, CST20, HTN1, SFO1, YDR002W, YD8119.08
    Database cross-references and differences (RAF-indexed):
    • Uniprot P41920
      • conflict (17)
      • conflict (36)
    Domains in SCOPe 2.04: d4gptb_
  • Chain 'C':
    Compound: Exportin-1
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: CRM1, KAP124, XPO1, YGR218W, G8514
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30822 (2-End)
      • expression tag (0-1)
      • engineered mutation (540)
      • engineered mutation (1023)
  • Heterogens: GNP, MG, EDO, CL, 51K, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4gptA (A:)
    maaqgepqvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpik
    fnvwdtagqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlc
    gnkvdikdrkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvamp
    alappevvmdpalaaqyehdlevaqttalpdedddl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4gptA (A:)
    vqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpikfnvwdtag
    qekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlcgnkvdikd
    rkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvampalappevv
    mdpalaaqyehdlevaqttalpdedddl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4gptB (B:)
    dihfepvvhlekvdvktaeedeevlykvraklfrfdkdakewkergtgdckflknkktnk
    vrilmrrdktlkicanhiiapeytlkpnvgsdrswvyactadiaegeaeaftfairfgsk
    enadkfkeefekaqeinkka
    

    Sequence, based on observed residues (ATOM records): (download)
    >4gptB (B:)
    taeedeevlykvraklfrfdkdakewkergtgdckflknkktnkvrilmrrdktlkican
    hiiapeytlkpnvgsdrswvyactadiaegeaeaftfairfgskenadkfkeefekaqei
    nkk
    

  • Chain 'C':
    No sequence available.