PDB entry 4g3y

View 4g3y on RCSB PDB site
Description: Crystal structure of TNF-alpha in complex with Infliximab Fab fragment
Class: immune system
Keywords: TNF, Infliximab, IMMUNE SYSTEM
Deposited on 2012-07-15, released 2013-03-27
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-08-07, with a file datestamp of 2013-08-02.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.191
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'C':
    Compound: Tumor necrosis factor
    Species: Homo sapiens [TaxId:9606]
    Gene: TNFA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4g3yc_
  • Chain 'H':
    Compound: infliximab Fab H
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4G3Y (0-End)
  • Chain 'L':
    Compound: infliximab Fab L
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4G3Y (0-213)
    Domains in SCOPe 2.05: d4g3yl1, d4g3yl2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4g3yC (C:)
vrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliys
qvlfkgqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiyl
ggvfqlekgdrlsaeinrpdyldfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >4g3yC (C:)
dkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqgc
psthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiylggvfqlekg
drlsaeinrpdyldfaesgqvyfgiial

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4g3yL (L:)
dilltqspailsvspgervsfscrasqfvgssihwyqqrtngsprllikyasesmsgips
rfsgsgsgtdftlsintvesediadyycqqshswpftfgsgtnlevkrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec