PDB entry 4fzi

View 4fzi on RCSB PDB site
Description: Crystal structure of prostaglandin F synthase from Trypanosoma cruzi
Class: oxidoreductase
Keywords: Structural Genomics, NIAID, National Institute of Allergy and Infectious Diseases, Seattle Structural Genomics Center for Infectious Disease, SSGCID, prostaglandin D2, trypanosomiasis, eukaryotic pathogen, parasite, NADP+, NADPH, rutin, bimatoprost, OXIDOREDUCTASE
Deposited on 2012-07-06, released 2012-07-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-06-03, with a file datestamp of 2015-05-29.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: prostaglandin F synthase
    Species: Trypanosoma cruzi [TaxId:353153]
    Gene: Tc00.1047053511287.49
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4DJ07
      • conflict (21)
      • conflict (58)
      • conflict (61)
      • conflict (64)
      • conflict (202-204)
      • conflict (206)
      • conflict (278-279)
    Domains in SCOPe 2.08: d4fzia_
  • Chain 'B':
    Compound: prostaglandin F synthase
    Species: Trypanosoma cruzi [TaxId:353153]
    Gene: Tc00.1047053511287.49
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4DJ07
      • conflict (21)
      • conflict (58)
      • conflict (61)
      • conflict (64)
      • conflict (206)
      • conflict (278-279)
    Domains in SCOPe 2.08: d4fzib_
  • Heterogens: GLU, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4fziA (A:)
mahhhhhhmncnyncvtlhnsvrmpqlglgvwraqdgaetanavrwaieagyrhidtayi
ysnergvgqgiresgvpreevwvttkvwnsdqgyektlaafersrellgleyidlylihw
pgkkkfvdtwkaleklyeekkvraigvsnfephhltelfksckirpmvnqvelhplfqqr
tlrefckqhniaitawsplgsgeeagilknhvlgeiakkhnkspaqvvirwdiqhgivti
pkstnkgriqenfnvwdfklteeemrqidelnedkrigadpdnffpggee

    Sequence, based on observed residues (ATOM records): (download) 
    >4fziA (A:)
yncvtlhnsvrmpqlglgvwraqdgaetanavrwaieagyrhidtayiysnergvgqgir
esgvpreevwvttkvwnsdqgyektlaafersrellgleyidlylihwpgkkkfvdtwka
leklyeekkvraigvsnfephhltelfksckirpmvnqvelhplfqqrtlrefckqhnia
itawsplgsgeeagilknhvlgeiakkhnkspaqvvirwdiqhgivtipkstnkgriqen
fnvwdfklteeemrqidelnedkrigadpdnffpgge

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4fziB (B:)
mahhhhhhmncnyncvtlhnsvrmpqlglgvwraqdgaetanavrwaieagyrhidtayi
ysnergvgqgiresgvpreevwvttkvwnsdqgyektlaafersrellgleyidlylihw
pgkkkfvdtwkaleklyeekkvraigvsnfephhltelfksckirpmvnqvelhplfqqr
tlrefckqhniaitawsplgsgeeagilknhvlgeiakkhnkspaqvvirwdiqhgivti
pkstnkgriqenfnvwdfklteeemrqidelnedkrigadpdnffpggee

    Sequence, based on observed residues (ATOM records): (download) 
    >4fziB (B:)
yncvtlhnsvrmpqlglgvwraqdgaetanavrwaieagyrhidtayiysnergvgqgir
esgvpreevwvttkvwnsdqgyektlaafersrellgleyidlylihwpgkkkfvdtwka
leklyeekkvraigvsnfephhltelfksckirpmvnqvelhplfqqrtlrefckqhnia
itawsplgsilknhvlgeiakkhnkspaqvvirwdiqhgivtipkstnkgriqenfnvwd
fklteeemrqidelnedkrigadpdnffpgg