PDB entry 4fz6
View 4fz6 on RCSB PDB site
Description: Crystal structure of spleen tyrosine kinase complexed with [6-((S)-2-Methyl-pyrrolidin-1-yl)-pyridin-2-yl]-(6-phenyl-imidazo[1,2-b]pyridazin-8-yl)-amine
Class: transferase/transferase inhibitor
Keywords: kinase inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2012-07-06, released
2013-01-30
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-07-17, with a file datestamp of
2019-07-12.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.36
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Tyrosine-protein kinase SYK
Species: Homo sapiens [TaxId:9606]
Gene: SYK
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4fz6a1, d4fz6a2 - Heterogens: 0VG, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4fz6A (A:)
maleeirpkevyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpa
lkdellaeanvmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdknii
elvhqvsmgmkyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthg
kwpvkwyapecinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermg
cpagcpremydlmnlcwtydvenrpgfaavelrlrnyyydvvneghhhhhh
Sequence, based on observed residues (ATOM records): (download)
>4fz6A (A:)
vyldrklltledkelgsfgtvkkgyyqmkkvvktvavkilkpalkdellaeanvmqqldn
pyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkyleesn
fvhrdlaarnvllvtqhyakisdfglskalradenyykakwpvkwyapecinyykfssks
dvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcwtydv
enrpgfaavelrlrnyyydvvneghh