PDB entry 4foa

View 4foa on RCSB PDB site
Description: Crystal Structure of the Mtb ThyA in Complex with 5-fluoro-dUMP
Class: transferase
Keywords: Structural Genomics, TB Structural Genomics Consortium, TBSGC, transferase, thymidylate synthase
Deposited on 2012-06-20, released 2013-08-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Gene: MT2834, MTV002.29c, Rv2764c, thyA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P67044 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.08: d4foaa1, d4foaa2
  • Chain 'B':
    Compound: Thymidylate synthase
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Gene: MT2834, MTV002.29c, Rv2764c, thyA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4foab_
  • Chain 'C':
    Compound: Thymidylate synthase
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Gene: MT2834, MTV002.29c, Rv2764c, thyA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4foac_
  • Chain 'D':
    Compound: Thymidylate synthase
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Gene: MT2834, MTV002.29c, Rv2764c, thyA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4foad_
  • Heterogens: UFP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4foaA (A:)
smtpyedllrfvletgtpksdrtgtgtrslfgqqmrydlsagfpllttkkvhfksvayel
lwflrgdsnigwlhehgvtiwdewasdtgelgpiygvqwrswpapsgehidqisaaldll
rtdpdsrriivsawnvgeiermalppchaffqfyvadgrlscqlyqrsadlflgvpfnia
syallthmmaaqaglsvgefiwtggdchiydnhveqvrlqlsreprpypkllladrdsif
eytyedivvknydphpaikapvav

    Sequence, based on observed residues (ATOM records): (download) 
    >4foaA (A:)
smtpyedllrfvletgtpksdrtgtgtrslfgqqmrydlsagfpllttkkvhfksvayel
lwflrgdsnigwlhehgvtiwdewasdtgelgpiygvqwrswpapsgehidqisaaldll
rtdpdsrriivsawnvgeiermalppchaffqfyvadgrlscqlyqrsadlflgvpfnia
syallthmmaaqaglsvgefiwtggdchiydnhveqvrlqlsreprpypkllladrdsif
eytyedivvknydphpaikap

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4foaB (B:)
smtpyedllrfvletgtpksdrtgtgtrslfgqqmrydlsagfpllttkkvhfksvayel
lwflrgdsnigwlhehgvtiwdewasdtgelgpiygvqwrswpapsgehidqisaaldll
rtdpdsrriivsawnvgeiermalppchaffqfyvadgrlscqlyqrsadlflgvpfnia
syallthmmaaqaglsvgefiwtggdchiydnhveqvrlqlsreprpypkllladrdsif
eytyedivvknydphpaikapvav

    Sequence, based on observed residues (ATOM records): (download) 
    >4foaB (B:)
mtpyedllrfvletgtpksdtgtrslfgqqmrydlsagfpllttkkvhfksvayellwfl
rgdsnigwlhehgvtiwdewasdtgelgpiygvqwrswpapsgehidqisaaldllrtdp
dsrriivsawnvgeiermalppchaffqfyvadgrlscqlyqrsadlflgvpfniasyal
lthmmaaqaglsvgefiwtggdchiydnhveqvrlqlsreprpypkllladrdsifeyty
edivvknydphpaikapv

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4foaC (C:)
smtpyedllrfvletgtpksdrtgtgtrslfgqqmrydlsagfpllttkkvhfksvayel
lwflrgdsnigwlhehgvtiwdewasdtgelgpiygvqwrswpapsgehidqisaaldll
rtdpdsrriivsawnvgeiermalppchaffqfyvadgrlscqlyqrsadlflgvpfnia
syallthmmaaqaglsvgefiwtggdchiydnhveqvrlqlsreprpypkllladrdsif
eytyedivvknydphpaikapvav

    Sequence, based on observed residues (ATOM records): (download) 
    >4foaC (C:)
mtpyedllrfvletgtpksdrtgtgtrslfgqqmrydlsagfpllttkkvhfksvayell
wflrgdsnigwlhehgvtiwdewasdtgelgpiygvqwrswpapsgehidqisaaldllr
tdpdsrriivsawnvgeiermalppchaffqfyvadgrlscqlyqrsadlflgvpfnias
yallthmmaaqaglsvgefiwtggdchiydnhveqvrlqlsreprpypkllladrdsife
ytyedivvknydphpaikap

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4foaD (D:)
smtpyedllrfvletgtpksdrtgtgtrslfgqqmrydlsagfpllttkkvhfksvayel
lwflrgdsnigwlhehgvtiwdewasdtgelgpiygvqwrswpapsgehidqisaaldll
rtdpdsrriivsawnvgeiermalppchaffqfyvadgrlscqlyqrsadlflgvpfnia
syallthmmaaqaglsvgefiwtggdchiydnhveqvrlqlsreprpypkllladrdsif
eytyedivvknydphpaikapvav

    Sequence, based on observed residues (ATOM records): (download) 
    >4foaD (D:)
mtpyedllrfvletgtpksdrtgtgtrslfgqqmrydlsagfpllttkkvhfksvayell
wflrgdsnigwlhehgvtiwdewasdtgelgpiygvqwrswpapsgehidqisaaldllr
tdpdsrriivsawnvgeiermalppchaffqfyvadgrlscqlyqrsadlflgvpfnias
yallthmmaaqaglsvgefiwtggdchiydnhveqvrlqlsreprpypkllladrdsife
ytyedivvknydphpaikapv