PDB entry 4flc

View 4flc on RCSB PDB site
Description: Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and the R303C ADSL Deficiency Associated Mutation
Class: lyase
Keywords: purine biosynthesis, lyase, disease mutation, purine metabolism
Deposited on 2012-06-14, released 2012-08-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-09-12, with a file datestamp of 2012-09-07.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.234
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: adenylosuccinate lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: ADSL, AMPS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30566
      • conflict (65)
      • engineered mutation (305)
    Domains in SCOPe 2.08: d4flca_
  • Chain 'B':
    Compound: adenylosuccinate lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: ADSL, AMPS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30566
      • conflict (65)
      • engineered mutation (305)
    Domains in SCOPe 2.08: d4flcb_
  • Chain 'C':
    Compound: adenylosuccinate lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: ADSL, AMPS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30566
      • conflict (65)
      • engineered mutation (305)
    Domains in SCOPe 2.08: d4flcc_
  • Chain 'D':
    Compound: adenylosuccinate lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: ADSL, AMPS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30566
      • conflict (65)
      • engineered mutation (305)
    Domains in SCOPe 2.08: d4flcd_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4flcA (A:)
    gshmaaggdhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpi
    tdeqiremksnlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgd
    ntdliilrnaldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiq
    dlcmdlqnlkrvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafi
    itgqtytrkvdievlsvlaslgasvhkictdirllanlkemeepfekqqigssampykrn
    pmrsecccslarhlmtlvmdplqtasvqwfertlddsanrriclaeafltadtilntlqn
    iseglvvypkvierrirqelpfmateniimamvkaggsrqdchekirvlsqqaasvvkqe
    ggdndlieriqvdayfspihsqldhlldpssftgrasqqvqrfleeevypllkpyesvmk
    vkaelcl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4flcA (A:)
    hgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpitdeqiremk
    snlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgdntdliilrn
    aldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiqdlcmdlqnl
    krvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafiitgqtytrk
    vdievlsvlaslgasvhkictdirllanlkemeepfekqqipykrnpmrsecccslarhl
    mtlvmdplqtasvqwfertlddsanrriclaeafltadtilntlqniseglvvypkvier
    rirqelpfmateniimamvrqdchekirvlsqqaasvvkqeggdndlieriqvdayfspi
    hsqldhlldpssftgrasqqvqrfleeevypllkpyesvm
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4flcB (B:)
    gshmaaggdhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpi
    tdeqiremksnlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgd
    ntdliilrnaldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiq
    dlcmdlqnlkrvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafi
    itgqtytrkvdievlsvlaslgasvhkictdirllanlkemeepfekqqigssampykrn
    pmrsecccslarhlmtlvmdplqtasvqwfertlddsanrriclaeafltadtilntlqn
    iseglvvypkvierrirqelpfmateniimamvkaggsrqdchekirvlsqqaasvvkqe
    ggdndlieriqvdayfspihsqldhlldpssftgrasqqvqrfleeevypllkpyesvmk
    vkaelcl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4flcB (B:)
    gdhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpitdeqire
    mksnlenidfkmaaeeekrlrhdvmahvhtfghccaagiihlgatscyvgdntdliilrn
    aldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiqdlcmdlqnl
    krvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafiitgqtytrk
    vdievlsvlaslgasvhkictdirllanlkemeepfekqqampykrnpmrsecccslarh
    lmtlvmdplqtasvqwfertlddsanrriclaeafltadtilntlqniseglvvypkvie
    rrirqelpfmateniimamvkaggsrqdchekirvlsqqaasvvkqeggdndlieriqvd
    ayfspihsqldhlldpssftgrasqqvqrfleeevypllkpyes
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4flcC (C:)
    gshmaaggdhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpi
    tdeqiremksnlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgd
    ntdliilrnaldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiq
    dlcmdlqnlkrvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafi
    itgqtytrkvdievlsvlaslgasvhkictdirllanlkemeepfekqqigssampykrn
    pmrsecccslarhlmtlvmdplqtasvqwfertlddsanrriclaeafltadtilntlqn
    iseglvvypkvierrirqelpfmateniimamvkaggsrqdchekirvlsqqaasvvkqe
    ggdndlieriqvdayfspihsqldhlldpssftgrasqqvqrfleeevypllkpyesvmk
    vkaelcl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4flcC (C:)
    spdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpitdeqiremksn
    lenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgdntdliilrnal
    dlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiqdlcmdlqnlkr
    vrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafiitgqtytrkvd
    ievlsvlaslgasvhkictdirllanlkemeepfnpmrsecccslarhlmtlvmdplqta
    svqwfertlddsanrriclaeafltadtilntlqniseglvvypkvierrirqelpfmat
    eniimamvkaggsrqdchekirvlsqqaasvvkqeggdndlieriqvdayfspihsqldh
    lldpssftgrasqqvqrfleeevypllkpyesv
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4flcD (D:)
    gshmaaggdhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpi
    tdeqiremksnlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgd
    ntdliilrnaldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiq
    dlcmdlqnlkrvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafi
    itgqtytrkvdievlsvlaslgasvhkictdirllanlkemeepfekqqigssampykrn
    pmrsecccslarhlmtlvmdplqtasvqwfertlddsanrriclaeafltadtilntlqn
    iseglvvypkvierrirqelpfmateniimamvkaggsrqdchekirvlsqqaasvvkqe
    ggdndlieriqvdayfspihsqldhlldpssftgrasqqvqrfleeevypllkpyesvmk
    vkaelcl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4flcD (D:)
    gdhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpitdeqire
    mksnlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgdntdliil
    rnaldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiqdlcmdlq
    nlkrvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafiitgqtyt
    rkvdievlsvlaslgasvhkictdirllanlkemeepfekqpykrnpmrsecccslarhl
    mtlvmdplqtasvqwfertlddsanrriclaeafltadtilntlqniseglvvypkvier
    rirqelpfmateniimamvkaggsrqdchekirvlsqqaasvvkqeggdndlieriqvda
    yfspihsqldhlldpssftgrasqqvqrfleeevypllkpye