PDB entry 4fjy

View 4fjy on RCSB PDB site
Description: Crystal structure of PI3K-gamma in complex with quinoline-indoline inhibitor 24f
Class: Transferase/Inhibitor
Keywords: inflammation, cancer, p110, C2 domain, leukocytes, kinase, p85, phosphotransferase, Transferase-Inhibitor complex
Deposited on 2012-06-12, released 2012-10-24
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-10-24, with a file datestamp of 2012-10-19.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.203
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3CG
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4fjya1, d4fjya2, d4fjya3, d4fjya4
  • Heterogens: SO4, FJY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4fjyA (A:)
gseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwv
tskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdip
esqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkee
wplvddctgvtgyheqltihgkdhesvftvslwdcdrkfrvkirgidipvlprntdltvf
veaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgkapals
skasaespsseskgkvqllyyvnlllidhrfllrrgeyvlhmwqisgkgedqgsfnadkl
tsatnpdkensmsisilldnychpialpkhqptpdpegdrvraempnqlrkqleaiiatd
plnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarrevwdqsal
dvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsalarfll
krglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqvqvieml
qkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpydpglkagalaiekck
vmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwetesldl
cllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkekspteekfq
aaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgnyksflginker
vpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpql
tskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlgikqgekhsa

    Sequence, based on observed residues (ATOM records): (download) 
    >4fjyA (A:)
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfdfvlrvcgrdeylvg
etpiknfqwvrhclkngeeihvvldtppdpaldevrketvslwdcdrkfrvkirgidipv
ldltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycg
kvqllyyvnlllidhrfllrrgeyvlhmwqissfnadkltsatnpdkensmsisilldnp
ialpkhqvraempnqlrkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfss
vkwgqqeivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraiavqklesleddd
vlhyllqlvqavkfepyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfav
ileaylrgcgtamlhdftqqvqviemlqkvtldikslsaedvssqvisqlkqklenlqns
qlpesfrvpydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgdd
lrqdmlilqilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvg
ntgafkdevlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitet
gnlfhidfghiervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnllii
lfsmmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwfl