PDB entry 4f8e

View 4f8e on RCSB PDB site
Description: Crystal structure of human PRS1 D52H mutant
Class: transferase
Keywords: PRPP synthesis, TRANSFERASE
Deposited on 2012-05-17, released 2013-05-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-03-12, with a file datestamp of 2014-03-07.
Experiment type: XRAY
Resolution: 2.27 Å
R-factor: 0.178
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ribose-phosphate pyrophosphokinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PRPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P60891
      • engineered mutation (51)
    Domains in SCOPe 2.08: d4f8ea1, d4f8ea2
  • Chain 'B':
    Compound: Ribose-phosphate pyrophosphokinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PRPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P60891
      • engineered mutation (51)
    Domains in SCOPe 2.08: d4f8eb1, d4f8eb2
  • Heterogens: SO4, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4f8eA (A:)
mpnikifsgsshqdlsqkiadrlglelgkvvtkkfsnqetcveigesvrgehvyivqsgc
geindnlmelliminackiasasrvtavipcfpyarqdkkdksrapisaklvanmlsvag
adhiitmdlhasqiqgffdipvdnlyaepavlkwirenisewrnctivspdaggakrvts
iadrlnvdfalihkerkkanevdrmvlvgdvkdrvailvddmadtcgtichaadkllsag
atrvyailthgifsgpaisrinnacfeavvvtntipqedkmkhcskiqvidismilaeai
rrthngesvsylfshvpllehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4f8eA (A:)
pnikifsgsshqdlsqkiadrlglelgkvvtkkfsnqetcveigesvrgehvyivqsgcg
eindnlmelliminackiasasrvtavipcfpyarqdkkdksrapisaklvanmlsvaga
dhiitmdlhasqiqgffdipvdnlyaepavlkwirenisewrnctivspdaggakrvtsi
adrlnvdfalihkerrmvlvgdvkdrvailvddmadtcgtichaadkllsagatrvyail
thgifsgpaisrinnacfeavvvtntipqedkmkhcskiqvidismilaeairrthnges
vsylfshv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4f8eB (B:)
mpnikifsgsshqdlsqkiadrlglelgkvvtkkfsnqetcveigesvrgehvyivqsgc
geindnlmelliminackiasasrvtavipcfpyarqdkkdksrapisaklvanmlsvag
adhiitmdlhasqiqgffdipvdnlyaepavlkwirenisewrnctivspdaggakrvts
iadrlnvdfalihkerkkanevdrmvlvgdvkdrvailvddmadtcgtichaadkllsag
atrvyailthgifsgpaisrinnacfeavvvtntipqedkmkhcskiqvidismilaeai
rrthngesvsylfshvpllehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4f8eB (B:)
nikifsgsshqdlsqkiadrlglelgkvvtkkfsnqetcveigesvrgehvyivqsgcge
indnlmelliminackiasasrvtavipcfpyarqdkkdksrapisaklvanmlsvagad
hiitmdlhasqiqgffdipvdnlyaepavlkwirenisewrnctivspdaggakrvtsia
drlnvdfalihkedrmvlvgdvkdrvailvddmadtcgtichaadkllsagatrvyailt
hgifsgpaisrinnacfeavvvtntipqedkmkhcskiqvidismilaeairrthngesv
sylfshvp