PDB entry 4f7i

View 4f7i on RCSB PDB site
Description: Structure of Isopropylmalate dehydrogenase from Thermus thermophilus in complex with IPM, Mn and NADH
Class: oxidoreductase
Keywords: isopropylmalate dehydrogenase, 3-ipm-dh, beta-ipm dehydrogenase, imdh, ipmdh, oxidoreductase
Deposited on 2012-05-16, released 2012-06-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-09-04, with a file datestamp of 2019-08-30.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-isopropylmalate dehydrogenase
    Species: Thermus thermophilus [TaxId:300852]
    Gene: leuB, TTHA1230
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5SIY4 (3-347)
      • expression tag (2)
      • expression tag (348-351)
    Domains in SCOPe 2.08: d4f7ia1, d4f7ia2, d4f7ia3
  • Chain 'B':
    Compound: 3-isopropylmalate dehydrogenase
    Species: Thermus thermophilus [TaxId:300852]
    Gene: leuB, TTHA1230
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5SIY4 (3-347)
      • expression tag (2)
      • expression tag (348-351)
    Domains in SCOPe 2.08: d4f7ib1, d4f7ib2, d4f7ib3
  • Chain 'C':
    Compound: 3-isopropylmalate dehydrogenase
    Species: Thermus thermophilus [TaxId:300852]
    Gene: leuB, TTHA1230
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5SIY4 (3-347)
      • expression tag (2)
      • expression tag (348-349)
    Domains in SCOPe 2.08: d4f7ic1, d4f7ic2, d4f7ic3
  • Chain 'D':
    Compound: 3-isopropylmalate dehydrogenase
    Species: Thermus thermophilus [TaxId:300852]
    Gene: leuB, TTHA1230
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5SIY4 (3-347)
      • expression tag (2)
      • expression tag (348-350)
    Domains in SCOPe 2.08: d4f7id1, d4f7id2, d4f7id3
  • Heterogens: IPM, NAD, MPO, MN, K, GOL, EOH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4f7iA (A:)
masmkvavlpgdgigpevteaalkvlraldeaeglglayevfpfggaaidafgepfpept
rkgveeaeavllgsvggpkwdglprkirpetgllslrksqdlfanlrpakvfpglerlsp
lkeeiargvdvlivreltggiyfgeprgmseaeawnteryskpevervarvafeaarkrr
khvvsvdkanvlevgefwrktveevgrgypdvalehqyvdamamhlvrsparfdvvvtgn
ifgdilsdlasvlpgslgllpsaslgrgtpvfepvhgsapdiagkgianptaailsaamm
lehafglvelarkvedavakalletpppdlggsagteaftatvlrhlaaaalehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4f7iA (A:)
smkvavlpgdgigpevteaalkvlraldeaeglglayevfpfggaaidafgepfpeptrk
gveeaeavllgsvggpkwdglprkirpetgllslrksqdlfanlrpakvfpglerlsplk
eeiargvdvlivreltggiyfgeprgmseaeawnteryskpevervarvafeaarkrrkh
vvsvdkanvlevgefwrktveevgrgypdvalehqyvdamamhlvrsparfdvvvtgnif
gdilsdlasvlpgslgllpsaslgrgtpvfepvhgsapdiagkgianptaailsaammle
hafglvelarkvedavakalletpppdlggsagteaftatvlrhlaaaal

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4f7iB (B:)
masmkvavlpgdgigpevteaalkvlraldeaeglglayevfpfggaaidafgepfpept
rkgveeaeavllgsvggpkwdglprkirpetgllslrksqdlfanlrpakvfpglerlsp
lkeeiargvdvlivreltggiyfgeprgmseaeawnteryskpevervarvafeaarkrr
khvvsvdkanvlevgefwrktveevgrgypdvalehqyvdamamhlvrsparfdvvvtgn
ifgdilsdlasvlpgslgllpsaslgrgtpvfepvhgsapdiagkgianptaailsaamm
lehafglvelarkvedavakalletpppdlggsagteaftatvlrhlaaaalehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4f7iB (B:)
smkvavlpgdgigpevteaalkvlraldeaeglglayevfpfggaaidafgepfpeptrk
gveeaeavllgsvggpkwdglprkirpetgllslrksqdlfanlrpakvfpglerlsplk
eeiargvdvlivreltggiyfgeprgmseaeawnteryskpevervarvafeaarkrrkh
vvsvdkanvlevgefwrktveevgrgypdvalehqyvdamamhlvrsparfdvvvtgnif
gdilsdlasvlpgslgllpsaslgrgtpvfepvhgsapdiagkgianptaailsaammle
hafglvelarkvedavakalletpppdlggsagteaftatvlrhlaaaal

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4f7iC (C:)
masmkvavlpgdgigpevteaalkvlraldeaeglglayevfpfggaaidafgepfpept
rkgveeaeavllgsvggpkwdglprkirpetgllslrksqdlfanlrpakvfpglerlsp
lkeeiargvdvlivreltggiyfgeprgmseaeawnteryskpevervarvafeaarkrr
khvvsvdkanvlevgefwrktveevgrgypdvalehqyvdamamhlvrsparfdvvvtgn
ifgdilsdlasvlpgslgllpsaslgrgtpvfepvhgsapdiagkgianptaailsaamm
lehafglvelarkvedavakalletpppdlggsagteaftatvlrhlaaaalehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4f7iC (C:)
smkvavlpgdgigpevteaalkvlraldeaeglglayevfpfggaaidafgepfpeptrk
gveeaeavllgsvggpkwdglprkirpetgllslrksqdlfanlrpakvfpglerlsplk
eeiargvdvlivreltggiyfgeprgmseaeawnteryskpevervarvafeaarkrrkh
vvsvdkanvlevgefwrktveevgrgypdvalehqyvdamamhlvrsparfdvvvtgnif
gdilsdlasvlpgslgllpsaslgrgtpvfepvhgsapdiagkgianptaailsaammle
hafglvelarkvedavakalletpppdlggsagteaftatvlrhlaaa

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4f7iD (D:)
masmkvavlpgdgigpevteaalkvlraldeaeglglayevfpfggaaidafgepfpept
rkgveeaeavllgsvggpkwdglprkirpetgllslrksqdlfanlrpakvfpglerlsp
lkeeiargvdvlivreltggiyfgeprgmseaeawnteryskpevervarvafeaarkrr
khvvsvdkanvlevgefwrktveevgrgypdvalehqyvdamamhlvrsparfdvvvtgn
ifgdilsdlasvlpgslgllpsaslgrgtpvfepvhgsapdiagkgianptaailsaamm
lehafglvelarkvedavakalletpppdlggsagteaftatvlrhlaaaalehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4f7iD (D:)
smkvavlpgdgigpevteaalkvlraldeaeglglayevfpfggaaidafgepfpeptrk
gveeaeavllgsvggpkwdglprkirpetgllslrksqdlfanlrpakvfpglerlsplk
eeiargvdvlivreltggiyfgeprgmseaeawnteryskpevervarvafeaarkrrkh
vvsvdkanvlevgefwrktveevgrgypdvalehqyvdamamhlvrsparfdvvvtgnif
gdilsdlasvlpgslgllpsaslgrgtpvfepvhgsapdiagkgianptaailsaammle
hafglvelarkvedavakalletpppdlggsagteaftatvlrhlaaaa