PDB entry 4f21

View 4f21 on RCSB PDB site
Description: Crystal structure of carboxylesterase/phospholipase family protein from Francisella tularensis
Class: hydrolase/hydrolase inhibitor
Keywords: Structural Genomics, NIAID, National Institute of Allergy and Infectious Diseases, Center for Structural Genomics of Infectious Diseases, CSGID, carboxylesterase, phospholipase, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2012-05-07, released 2012-08-29
The last revision prior to the SCOPe 2.04 freeze date was dated 2013-10-09, with a file datestamp of 2013-10-04.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.204
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carboxylesterase/phospholipase family protein
    Species: Francisella tularensis subsp. tularensis [TaxId:177416]
    Gene: FTT_0258
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5NI32 (24-245)
      • expression tag (22-23)
    Domains in SCOPe 2.04: d4f21a_
  • Chain 'B':
    Compound: Carboxylesterase/phospholipase family protein
    Species: Francisella tularensis subsp. tularensis [TaxId:177416]
    Gene: FTT_0258
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5NI32 (24-245)
      • expression tag (22-23)
    Domains in SCOPe 2.04: d4f21b_
  • Chain 'C':
    Compound: Carboxylesterase/phospholipase family protein
    Species: Francisella tularensis subsp. tularensis [TaxId:177416]
    Gene: FTT_0258
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5NI32 (24-245)
      • expression tag (22-23)
    Domains in SCOPe 2.04: d4f21c_
  • Chain 'D':
    Compound: Carboxylesterase/phospholipase family protein
    Species: Francisella tularensis subsp. tularensis [TaxId:177416]
    Gene: FTT_0258
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5NI32 (24-245)
      • expression tag (22-23)
    Domains in SCOPe 2.04: d4f21d_
  • Chain 'E':
    Compound: Carboxylesterase/phospholipase family protein
    Species: Francisella tularensis subsp. tularensis [TaxId:177416]
    Gene: FTT_0258
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5NI32 (24-245)
      • expression tag (21-23)
    Domains in SCOPe 2.04: d4f21e_
  • Chain 'F':
    Compound: Carboxylesterase/phospholipase family protein
    Species: Francisella tularensis subsp. tularensis [TaxId:177416]
    Gene: FTT_0258
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5NI32 (24-245)
      • expression tag (21-23)
    Domains in SCOPe 2.04: d4f21f_
  • Chain 'G':
    Compound: Carboxylesterase/phospholipase family protein
    Species: Francisella tularensis subsp. tularensis [TaxId:177416]
    Gene: FTT_0258
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5NI32 (24-245)
      • expression tag (21-23)
    Domains in SCOPe 2.04: d4f21g_
  • Chain 'H':
    Compound: Carboxylesterase/phospholipase family protein
    Species: Francisella tularensis subsp. tularensis [TaxId:177416]
    Gene: FTT_0258
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5NI32 (24-245)
      • expression tag (21-23)
    Domains in SCOPe 2.04: d4f21h_
  • Heterogens: 0S1, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4f21A (A:)
mhhhhhhssgvdlgtenlyfqsnamnyelmepakqarfcviwlhglgadghdfvdivnyf
dvsldeirfifphadiipvtinmgmqmrawydiksldanslnrvvdveginssiakvnkl
idsqvnqgiaseniilagfsqggiiatytaitsqrklggimalstylpawdnfkgkitsi
nkglpilvchgtddqvlpevlghdlsdklkvsgfaneykhyvgmqhsvcmeeikdisnfi
aktfki

    Sequence, based on observed residues (ATOM records): (download) 
    >4f21A (A:)
namnyelmepakqarfcviwlhgadghdfvdivnyfdvsldeirfifphadiipvtinmg
mqmrawydikslslnrvvdveinssiakvnklidsqvnqiaseniilagfsqggiiatyt
aitsqrklggimalstylpawdnfkgkitsinkglpilvchgtddqvlpevlghdlsdkl
kvsgfaneykhyvgmqhsvcmeeikdisnfiaktfki

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4f21B (B:)
mhhhhhhssgvdlgtenlyfqsnamnyelmepakqarfcviwlhglgadghdfvdivnyf
dvsldeirfifphadiipvtinmgmqmrawydiksldanslnrvvdveginssiakvnkl
idsqvnqgiaseniilagfsqggiiatytaitsqrklggimalstylpawdnfkgkitsi
nkglpilvchgtddqvlpevlghdlsdklkvsgfaneykhyvgmqhsvcmeeikdisnfi
aktfki

    Sequence, based on observed residues (ATOM records): (download) 
    >4f21B (B:)
namnyelmepakqarfcviwlhgadghdfvdivnyfdvsldeirfifphadiipvtinmg
mqmrawydiksldslnrvvdveginssiakvnklidsqvnqgiaseniilagfsqggiia
tytaitsqrklggimalstylpawdnfkgkitsinkglpilvchgtddqvlpevlghdls
dklkvsgfaneykhyvgmqhsvcmeeikdisnfiaktfki

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4f21C (C:)
mhhhhhhssgvdlgtenlyfqsnamnyelmepakqarfcviwlhglgadghdfvdivnyf
dvsldeirfifphadiipvtinmgmqmrawydiksldanslnrvvdveginssiakvnkl
idsqvnqgiaseniilagfsqggiiatytaitsqrklggimalstylpawdnfkgkitsi
nkglpilvchgtddqvlpevlghdlsdklkvsgfaneykhyvgmqhsvcmeeikdisnfi
aktfki

    Sequence, based on observed residues (ATOM records): (download) 
    >4f21C (C:)
namnyelmepakqarfcviwlhgadghdfvdivnyfdvsldeirfifphadiipvtinmg
mqmrawydiksldslnrvvdveginssiakvnklidsqvnqgiaseniilagfsqggiia
tytaitsqrklggimalstylpawdnfkgkitsinkglpilvchgtddqvlpevlghdls
dklkvsgfaneykhyvgmqhsvcmeeikdisnfiaktfki

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4f21D (D:)
mhhhhhhssgvdlgtenlyfqsnamnyelmepakqarfcviwlhglgadghdfvdivnyf
dvsldeirfifphadiipvtinmgmqmrawydiksldanslnrvvdveginssiakvnkl
idsqvnqgiaseniilagfsqggiiatytaitsqrklggimalstylpawdnfkgkitsi
nkglpilvchgtddqvlpevlghdlsdklkvsgfaneykhyvgmqhsvcmeeikdisnfi
aktfki

    Sequence, based on observed residues (ATOM records): (download) 
    >4f21D (D:)
namnyelmepakqarfcviwlhgadghdfvdivnyfdvsldeirfifphadiipvtinmg
mqmrawydiksldslnrvvdveginssiakvnklidsqvnqgiaseniilagfsqggiia
tytaitsqrklggimalstylpawdnfkgkitsinkglpilvchgtddqvlpevlghdls
dklkvsgfaneykhyvgmqhsvcmeeikdisnfiaktfki

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4f21E (E:)
mhhhhhhssgvdlgtenlyfqsnamnyelmepakqarfcviwlhglgadghdfvdivnyf
dvsldeirfifphadiipvtinmgmqmrawydiksldanslnrvvdveginssiakvnkl
idsqvnqgiaseniilagfsqggiiatytaitsqrklggimalstylpawdnfkgkitsi
nkglpilvchgtddqvlpevlghdlsdklkvsgfaneykhyvgmqhsvcmeeikdisnfi
aktfki

    Sequence, based on observed residues (ATOM records): (download) 
    >4f21E (E:)
snamnyelmepakqarfcviwlhglghdfvdivnyfdvsldeirfifphadigmqmrawy
diksvdveginssiakvnklidsqvnqgiaseniilagfsqggiiatytaitsqrklggi
malstylpawdnfkgkitsinkglpilvchgtddqvlpevlghdlsdklkvsgfaneykh
yvgmqhsvcmeeikdisnfiaktfki

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4f21F (F:)
mhhhhhhssgvdlgtenlyfqsnamnyelmepakqarfcviwlhglgadghdfvdivnyf
dvsldeirfifphadiipvtinmgmqmrawydiksldanslnrvvdveginssiakvnkl
idsqvnqgiaseniilagfsqggiiatytaitsqrklggimalstylpawdnfkgkitsi
nkglpilvchgtddqvlpevlghdlsdklkvsgfaneykhyvgmqhsvcmeeikdisnfi
aktfki

    Sequence, based on observed residues (ATOM records): (download) 
    >4f21F (F:)
snamnyelmepakqarfcviwlhglghdfvdivnyfdvsldeirfifphadimgmqmraw
ydiksveginssiakvnklidsqvnqgiaseniilagfsqggiiatytaitsqrklggim
alstylpawdnfkgkitsinkglpilvchgtddqvlpevlghdlsdklkvsgfaneykhy
vgmqhsvcmeeikdisnfiaktfki

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4f21G (G:)
mhhhhhhssgvdlgtenlyfqsnamnyelmepakqarfcviwlhglgadghdfvdivnyf
dvsldeirfifphadiipvtinmgmqmrawydiksldanslnrvvdveginssiakvnkl
idsqvnqgiaseniilagfsqggiiatytaitsqrklggimalstylpawdnfkgkitsi
nkglpilvchgtddqvlpevlghdlsdklkvsgfaneykhyvgmqhsvcmeeikdisnfi
aktfki

    Sequence, based on observed residues (ATOM records): (download) 
    >4f21G (G:)
snamnyelmepakqarfcviwlhhdfvdivnyfdvsldeirfifphaipvtigmqmrawy
dikvvdveginssikvnklidsqvnqgiaseniilagfsqggiiatytaitsqrklggim
alstylpawdnkgkitsinkglpilvchgtddqvlpevlghdlsdklkvsgfaneykhyv
gmqhsvcmeeikdisnfiaktfki

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4f21H (H:)
mhhhhhhssgvdlgtenlyfqsnamnyelmepakqarfcviwlhglgadghdfvdivnyf
dvsldeirfifphadiipvtinmgmqmrawydiksldanslnrvvdveginssiakvnkl
idsqvnqgiaseniilagfsqggiiatytaitsqrklggimalstylpawdnfkgkitsi
nkglpilvchgtddqvlpevlghdlsdklkvsgfaneykhyvgmqhsvcmeeikdisnfi
aktfki

    Sequence, based on observed residues (ATOM records): (download) 
    >4f21H (H:)
snamnyelmepakqarfcviwlhghdfvdivnyfdvsldeirfifphaipvtimrawydi
kvvdveginssiakvnklidsqvnqgiaseniilagfsqggiiatytaitsqrklggima
lstylpawdnfkgkitsinkglpilvchgtddqvlpevlghdlsdklkvsgfaneykhyv
gmqhsvcmeeikdisnfiaktfki