PDB entry 4f09

View 4f09 on RCSB PDB site
Description: Discovery and Optimization of C-2 Methyl Imidazo-pyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2
Class: transferase/transferase inhibitor
Keywords: JAK2, kinase domain, JH1 domain, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2012-05-03, released 2012-07-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-07-25, with a file datestamp of 2012-07-20.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.198
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2 kinase domain
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4f09a_
  • Heterogens: JAK, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4f09A (A:)
gssgafedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhstee
hlrdfereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridh
ikllqytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykv
kepgespifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkq
gqmivfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnm
ag

    Sequence, based on observed residues (ATOM records): (download) 
    >4f09A (A:)
qfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereieil
kslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsqick
gmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwya
peslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliell
knngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag