PDB entry 4ev4

View 4ev4 on RCSB PDB site
Description: Crystal structure of serratia fonticola carbapenemase SFC-1 E166A mutant with the acylenzyme intermediate of meropenem
Class: HYDROLASE/Antibiotic
Keywords: CARBAPENEMASE, HYDROLASE, ANTIBIOTIC RESISTANCE, BETA-LACTAMASE COMPLEX, HYDROLASE-Antibiotic complex
Deposited on 2012-04-25, released 2012-05-23
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-08-28, with a file datestamp of 2013-08-23.
Experiment type: XRAY
Resolution: 1.3 Å
R-factor: 0.116
AEROSPACI score: 0.82 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carbapenem-hydrolizing beta-lactamase SFC-1
    Species: Serratia fonticola [TaxId:47917]
    Gene: BLASFC-1, SFC-1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6JP75 (0-End)
      • engineered mutation (144)
      • see remark 999 (232)
      • see remark 999 (247)
    Domains in SCOPe 2.05: d4ev4a_
  • Heterogens: MER, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4ev4A (A:)
    asqppqvtvdklkrlendfggrigvyaidtgsnktfgyranerfplcssfkgflaaavls
    ksqqqegllnqrirydnrvmephspvtekqittgmtvaelsaatlqysdngaanlllekl
    iggpegmtsfmrsigdnvfrldrwalelnsaipgddrdtstpkavaesmqklafgnvlgl
    terhqlmdwfkgnttggarirasvpanwvvgdktgtcgvygtandyaviwpvahapivla
    vytskpdrnskhsdaviadasrivlesfnidalrmatgksigf
    

    Sequence, based on observed residues (ATOM records): (download)
    >4ev4A (A:)
    asqppqvtvdklkrlendfggrigvyaidtgsnktfgyranerfplcssfkgflaaavls
    ksqqqegllnqrirydnrvmephspvtekqittgmtvaelsaatlqysdngaanlllekl
    iggpegmtsfmrsigdnvfrldrwalelnsaipgddrdtstpkavaesmqklafgnvlgl
    terhqlmdwfkgnttggarirasvpanwvvgdktgtcgvygtandyaviwpvahapivla
    vytskpdrnskhsdaviadasrivlesfni