PDB entry 4er3

View 4er3 on RCSB PDB site
Description: Crystal Structure of Human DOT1L in complex with inhibitor EPZ004777
Class: Transferase/Transferase Inhibitor
Keywords: histone, methyltransferase, epigenetics, Transferase-Transferase Inhibitor complex, Structural Genomics, Structural Genomics Consortium, SGC
Deposited on 2012-04-19, released 2012-05-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-05-16, with a file datestamp of 2018-05-11.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone-lysine N-methyltransferase, H3 lysine-79 specific
    Species: Homo sapiens [TaxId:9606]
    Gene: DOT1L, KIAA1814, KMT4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4er3a_
  • Heterogens: 0QK, SO4, EDO, UNX, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4er3A (A:)
gmgeklelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyv
lidydtksfesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsv
tdpeklnnyepfspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnc
khhygvekadipakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvif
vnnfafgpevdhqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelspl
kgsvswtgkpvsyylhtidrtilenyfsslknpklreeqeaarrrqqresks

    Sequence, based on observed residues (ATOM records): (download) 
    >4er3A (A:)
klelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlidy
dtksfesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsvtdpe
klnnetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhygvekadipak
yaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnfafgpevdhql
kerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkgsvsyylhtidrt
ilenyfsslkn