PDB entry 4epx
View 4epx on RCSB PDB site
Description: Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation
Class: hydrolase
Keywords: small GTPase, Signaling transduction, Raf, Ral, Sos, PI3K, cytosol, binder, HYDROLASE, Inhibitor of Sos-mediated activation
Deposited on
2012-04-17, released
2012-05-23
The last revision prior to the SCOPe 2.04 freeze date was dated
2012-07-25, with a file datestamp of
2012-07-20.
Experiment type: XRAY
Resolution: 1.76 Å
R-factor: 0.154
AEROSPACI score: 0.56
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: GTPase KRas
Species: Homo sapiens [TaxId:9606]
Gene: KRAS, KRAS2, RASK2
Database cross-references and differences (RAF-indexed):
- Uniprot P01116 (1-169)
- expression tag (0)
- engineered mutation (12)
- engineered mutation (118)
Domains in SCOPe 2.04: d4epxa_ - Heterogens: GDP, MG, 0QR, HOH