PDB entry 4ept

View 4ept on RCSB PDB site
Description: Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation
Class: hydrolase
Keywords: small GTPase, Signaling transduction, SOS, Raf, Ral, PI3K, cytosol, binder, HYDROLASE
Deposited on 2012-04-17, released 2012-05-23
The last revision prior to the SCOPe 2.05 freeze date was dated 2012-07-25, with a file datestamp of 2012-07-20.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.232
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (1-End)
      • engineered mutation (118)
    Domains in SCOPe 2.05: d4epta_
  • Heterogens: GDP, MG, 0QW, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4eptA (A:)
    gmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
    gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnksd
    lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek
    

    Sequence, based on observed residues (ATOM records): (download)
    >4eptA (A:)
    mteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
    qeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnksdl
    psrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkh